594810-90-9

Basic information

• Product Name: 2-Bromo-4-fluorophenacyl bromide
• Synonyms: 2-Bromo-4-fluorophenacyl bromide;2,2'-Dibromo-4-fluoroacetophenone, 2-Bromo-1-(2-bromo-4-fluorophenyl)ethan-1-one
• CAS NO: 594810-90-9
• Molecular Formula: C8H5Br2FO
• Molecular Weight: 296
• Mol File: 594810-90-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Bromo-4-fluorophenacyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-fluorophenacyl bromide(594810-90-9)
• EPA Substance Registry System: 2-Bromo-4-fluorophenacyl bromide(594810-90-9)

Safety Data

• Hazardous Substances Data: 594810-90-9(Hazardous Substances Data)

Usage

Description

2-Bromo-4-fluorophenacyl bromide, also known as BFB, is a chemical compound that serves as a versatile reagent in the synthesis of pharmaceuticals and organic chemistry research. It is characterized by its high reactivity as a potent halogenating agent, which makes it useful in a wide range of chemical reactions. BFB is also known for its stability under typical storage conditions, contributing to its value in organic synthesis and pharmaceutical development.

Uses

Used in Pharmaceutical Synthesis:
2-Bromo-4-fluorophenacyl bromide is used as a key intermediate for the synthesis of various pharmaceuticals, leveraging its reactivity to form amides, esters, and other biologically active compounds that are integral to drug development.
Used in Organic Chemistry Research:
In the realm of organic chemistry, 2-Bromo-4-fluorophenacyl bromide is utilized as a research tool, enabling scientists to explore new reactions and mechanisms, thereby expanding the understanding of organic chemistry and its applications.
Used as a Coupling Reagent in Peptide Synthesis:
2-Bromo-4-fluorophenacyl bromide is employed as a coupling reagent in peptide synthesis, facilitating the formation of peptide bonds and contributing to the creation of complex peptide structures that are vital in biological research and drug design.
Used as a Precursor for Fluorescent Probes and Labels:
BFB is used as a precursor in the preparation of fluorescent probes and labels, capitalizing on its chemical properties to develop markers that are essential for various analytical and diagnostic applications in the life sciences.
Used in Organic Synthesis:
2-Bromo-4-fluorophenacyl bromide is utilized in organic synthesis as a valuable tool, taking advantage of its stability and reactivity to create a variety of organic compounds for diverse applications across different industries.

Upstream product

• 1006-39-9 1-(2-bromo-4-fluorophenyl)ethanone 

Relevant articles and documents

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Autotaxin (ATX) is a secreted enzyme playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis of lysophosphatidyl choline (LPC). The ATX-LPA signaling axis arouses a high interest in the drug discovery industry as it has been implicated in several diseases including cancer, fibrotic diseases, and inflammation, among others. An imidazo[1,2-a]pyridine series of ATX inhibitors was identified out of a high-throughput screening (HTS). A cocrystal structure with one of these compounds and ATX revealed a novel binding mode with occupancy of the hydrophobic pocket and channel of ATX but no interaction with zinc ions of the catalytic site. Exploration of the structure-activity relationship led to compounds displaying high activity in biochemical and plasma assays, exemplified by compound 40. Compound 40 was also able to decrease the plasma LPA levels upon oral administration to rats.

COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present invention discloses compounds according to Formula I: Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseasesby administering the compound of the invention.

BENZOFURAN DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS

The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.