1006-39-9

Basic information

• Product Name: 2'-BROMO-4'-FLUOROACETOPHENONE
• Synonyms: 2'-Bromo-4'-fluoroacetophenone 97%;2'-Bromo-4'-fluoroacetophenone97%;2'-Bromo-4'-Fluoroacetophenone;2'-Bromo-4'-fluoroacetophenone;1-Acetyl-2-bromo-4-fluorobenzene;1-(2-broMo-4-fluorophenyl)ethan-1-one;1-(2-BroMo-4-fluorophenyl)ethanone;Ethanone,1-(2-bromo-4-fluorophenyl)-
• CAS NO: 1006-39-9
• Molecular Formula: C₈H₆BrFO
• Molecular Weight: 217.04
• EINECS: -0
• Product Categories: Aromatic Halides (substituted);Benzene series;Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds;Aromatics;Miscellaneous Reagents
• Mol File: 1006-39-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 48-50°C
• Boiling Point: 150°C 12mm
• Flash Point: 110°C
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 0.0138mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: Refrigerator
• BRN: 2249797
• CAS DataBase Reference: 2'-BROMO-4'-FLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-BROMO-4'-FLUOROACETOPHENONE(1006-39-9)
• EPA Substance Registry System: 2'-BROMO-4'-FLUOROACETOPHENONE(1006-39-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36
• Hazardous Substances Data: 1006-39-9(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

InChI:InChI=1/C8H6BrFO/c1-5(11)7-3-2-6(10)4-8(7)9/h2-4H,1H3

Upstream product

• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 75-16-1 methylmagnesium bromide 
• 289038-17-1 (E)-3-(2-bromo-4-fluorophenyl)acrylic acid 
• 261711-20-0 1-(2-bromo-4-fluorophenyl)ethan-1-ol 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 7789-45-9 copper(II)bromide 
• 1073-06-9 3-fluorobromobenzene 
• 108-24-7 acetic anhydride 

Downstream Products

• 150162-43-9 Diethyl [4(4-fluorophenyl)-2-thiazolyl]-fluoromethyl-phosphonate 
• 1149344-98-8 6-(2-acetyl-5-fluorophenyl)benzo[d][1,3]dioxole-5-carbaldehyde 
• 1261497-12-4 1-(4-amino-2-bromophenyl)ethan-1-one 
• 1329166-62-2 [3-bromo-4-(2-bromo-acetyl)-phenyl]-carbamic acid methyl ester 
• 1329166-63-3 (4-acetyl-3-bromo-phenyl)-carbamic acid methyl ester 
• 1402452-23-6 6-fluoro-1-methyl-3-phenylisoquinoline 
• 1363508-10-4 2-acetyl-5-fluoro-benzonitrile 
• 1432037-02-9 C₉H₉FOS 

Relevant articles and documents

Intramolecular One-Carbon Homologation of Unstrained Ketones via C-C Activation-Enabled 1,1-Insertion of Alkenes

Here, we describe the development of a Rh-catalyzed intramolecular one-carbon homologation of unstrained aryl ketones through a formal 1,1-insertion process of olefins, enabled by temporary directing group (TDG)-aided C-C activation. The reaction provides a distinct approach to access various substituted 1-indanones. Computational mechanistic studies reveal that the formal 1,1-insertion is realized by a selective C(sp2)-C(sp3) activation and turnover limiting 2,1-insertion into the alkene, followed by a facile β-H elimination and reinsertion process.

The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes

In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.

Atmosphere-Controlled Palladium-Catalyzed Divergent Decarboxylative Cyclization of 2-Iodobiphenyls and α-Oxocarboxylic Acids

A novel palladium-catalyzed divergent decarboxylative cyclization of 2-iodobiphenyls and α-oxocarboxylic acids utilizing the atmosphere as a controlled switch is reported. Under the protection of a nitrogen atmosphere, tribenzotropones are synthesized by a [4 + 3] decarboxylative cyclization. Employing a palladium/O2 system enables a [4 + 2] decarboxylative cyclization to assemble triphenylenes. Notably, preliminary mechanistic studies indicate that the formation of triphenylenes involves a double decarboxylation.