59489-39-3

Basic information

• Product Name: Pyrazinecarbonitrile, 6-amino- (9CI)
• Synonyms: Pyrazinecarbonitrile, 6-amino- (9CI);2-Amino-6-cyanopyrazine;6-Aminopyrazine-2-carbonitrile;2-Amino-6-pyrazinecarbonitrile;2-Pyrazinecarbonitrile,6-amino-
• CAS NO: 59489-39-3
• Molecular Formula: C₅H₄N₄
• Molecular Weight: 120.11206
• Product Categories: VARIOUSAMINE;Building Blocks;Pyrazine
• Mol File: 59489-39-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 367.8ºC at 760 mmHg
• Flash Point: 176.3 ºC
• Appearance: /
• Density: 1.34 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Pyrazinecarbonitrile, 6-amino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinecarbonitrile, 6-amino- (9CI)(59489-39-3)
• EPA Substance Registry System: Pyrazinecarbonitrile, 6-amino- (9CI)(59489-39-3)

Safety Data

• Hazardous Substances Data: 59489-39-3(Hazardous Substances Data)

Usage

General Description

Pyrazinecarbonitrile, 6-amino- (9CI) is a chemical compound with the molecular formula C5H4N4. It is an aromatic compound that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its structure consists of a pyrazine ring with a cyano group (CN) and an amino group (NH2) attached in the 6-position. This chemical may be used in research and development for its potential therapeutic properties, but its specific biological and chemical properties are not widely documented. It is important to handle and use pyrazinecarbonitrile, 6-amino- (9CI) with caution, as it may have potential health and environmental hazards.

Upstream product

• 2423-65-6 Pyrazin-N-Oxid(PyzNO) 
• 98-96-4 pyrazinamide 
• 7677-24-9 trimethylsilyl cyanide 
• 6863-77-0 3-aminopyrazine 1-oxide 

Relevant articles and documents

Studies on Pyrazines. Part 22. Lewis Acid-Mediated Cyanation of Pyrazine N-Oxides with Trimethylsilyl Cyanide: New Route to 2-Substituted 3-Cyanopyrazines

Reaction of 3-substituted pyrazine 1-oxides with trimethylsilyl cyanide in the presence of triethylamine in acetonitrile gave the corresponding cyanopyrazines, yields of which depended remarkably on the substituent.Electron-donating groups enhanced the cyanation with high regioselectivity to 2-substituted 3-cyanopyrazines, while a chloro substituent suppressed the conversion.Addition of zinc halide to the reaction mixture, in most cases, increased the reactivity and improved the regioselectivity.On the other hand, the N-oxides carrying an electron-withdrawing methoxycarbonyl or N-butylcarbamoyl group underwent the cyanation, without need for the Lewis acid, to provide a mixture of nearly equal amounts of 2-substituted 3- and 5-cyanopyrazines.The latter compound was exclusively obtained when 3-methoxycarbonyl- or 3-cyanopyrazine 1-oxide was treated with diethoxyphosphoryl cyanide.