59489-39-3

Usage

Uses

Used in Pharmaceutical Industry:
Pyrazinecarbonitrile, 6-amino(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure with a pyrazine ring and functional groups allows for the development of new drugs with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, Pyrazinecarbonitrile, 6-amino(9CI) serves as a key intermediate in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the creation of effective compounds for crop protection and management.
Used in Research and Development:
Pyrazinecarbonitrile, 6-amino(9CI) is utilized in research and development for exploring its potential therapeutic properties and applications. Scientists and researchers investigate its chemical and biological characteristics to discover new uses and understand its mechanisms of action.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 6863-77-0 3-aminopyrazine 1-oxide 
• 2423-65-6 Pyrazin-N-Oxid(PyzNO) 
• 98-96-4 pyrazinamide 

Relevant academic research and scientific papers

Studies on Pyrazines. Part 22. Lewis Acid-Mediated Cyanation of Pyrazine N-Oxides with Trimethylsilyl Cyanide: New Route to 2-Substituted 3-Cyanopyrazines

Reaction of 3-substituted pyrazine 1-oxides with trimethylsilyl cyanide in the presence of triethylamine in acetonitrile gave the corresponding cyanopyrazines, yields of which depended remarkably on the substituent.Electron-donating groups enhanced the cyanation with high regioselectivity to 2-substituted 3-cyanopyrazines, while a chloro substituent suppressed the conversion.Addition of zinc halide to the reaction mixture, in most cases, increased the reactivity and improved the regioselectivity.On the other hand, the N-oxides carrying an electron-withdrawing methoxycarbonyl or N-butylcarbamoyl group underwent the cyanation, without need for the Lewis acid, to provide a mixture of nearly equal amounts of 2-substituted 3- and 5-cyanopyrazines.The latter compound was exclusively obtained when 3-methoxycarbonyl- or 3-cyanopyrazine 1-oxide was treated with diethoxyphosphoryl cyanide.

Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas

Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas, active as insecticides, and methods for their use as insecticides.