59504-31-3

Usage

Uses

Used in Organic Synthesis:
1-(4,5-dichloro-2-nitrophenyl)pyrrolidine is used as a building block in the field of organic synthesis for the preparation of various pharmaceuticals and bioactive compounds. Its unique structure allows for the creation of a wide range of molecules with potential applications in the medical and pharmaceutical industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4,5-dichloro-2-nitrophenyl)pyrrolidine is used as a key intermediate for the development of new drugs. Its properties make it a promising candidate for the synthesis of molecules with therapeutic potential.
Used in Antimicrobial Applications:
1-(4,5-dichloro-2-nitrophenyl)pyrrolidine has been studied for its potential antimicrobial properties. It is used as an active compound in the development of new antimicrobial agents to combat bacterial infections.
Used in Antifungal Applications:
Similarly, 1-(4,5-dichloro-2-nitrophenyl)pyrrolidine has also been investigated for its antifungal properties. It is utilized as a starting material in the synthesis of antifungal agents to treat fungal infections.

Upstream product

• 120-94-5 1-Methylpyrrolidine 
• 89-69-0 2,4,5-Trichloronitrobenzene 
• 123-75-1 pyrrolidine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Based on the X-ray crystallography of our lead compound 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea in the checkpoint kinase 1 (Chk1) enzyme, we modified R4, and to a lesser extent, R2, and R5 of the phenyl ring, and made a variety of N-aryl-N′-pyrazinylurea Chk1 inhibitors. Enzymatic activity less than 20 nM was observed in 15 of 41 compounds. Compound 8i provided the best overall results in the cellular assays as it abrogated doxorubicin-induced cell cycle arrest (IC50 = 1.7 μM) and enhanced doxorubicin cytotoxicity (IC50 = 0.44 μM) while displaying no single agent activity.

Reaction of Mono-, Di-, and Trichloronitrobenzenes with N-Methyl Substituted Cyclic Tertiary Amines under High Pressure

The reactions of mono-, di-, and trichloronitrobenzenes with 1-methylpyrrolidine under high pressure gave products of demethylation and ring-opening through a quaternary pyrrolidinium chloride intermediate formed by the SNAr reaction.On the other hand, the reactions with 1-methylpiperidine and 4-methylmorpholine gave only demethylation products.The selectivities of the resctions of 1-methylpyrrolidine with these chloronitrobenzenes were found to be effected by the neighboring substituent to the pyrrolidinium group.