59507-53-8

Basic information

• Product Name: (3-bromophenylcarbonyl)piperidine
• Synonyms: (3-bromophenylcarbonyl)piperidine;1-(3-bromobenzoyl)piperidine(SALTDATA: FREE)
• CAS NO: 59507-53-8
• Molecular Formula: C₁₂H₁₄BrNO
• Molecular Weight: 268.15
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 59507-53-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 379.9°C at 760 mmHg
• Flash Point: 183.5°C
• Appearance: /
• Density: 1.406g/cm³
• Vapor Pressure: 5.67E-06mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (3-bromophenylcarbonyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3-bromophenylcarbonyl)piperidine(59507-53-8)
• EPA Substance Registry System: (3-bromophenylcarbonyl)piperidine(59507-53-8)

Safety Data

• Hazardous Substances Data: 59507-53-8(Hazardous Substances Data)

Usage

General Description

(3-bromophenylcarbonyl)piperidine is an organic chemical compound that consists of a piperidine ring with a bromophenylcarbonyl group attached to it. It is commonly used as a building block or intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential neurological or psychiatric applications. (3-bromophenylcarbonyl)piperidine has been studied for its potential as a dopamine receptor agonist and has also been investigated for its potential as a therapeutic agent for conditions such as schizophrenia and Parkinson's disease. Additionally, it has been used in the development of new ligands for studies of the nicotinic acetylcholine receptor. As a chemical of interest to researchers and pharmaceutical companies, (3-bromophenylcarbonyl)piperidine is a versatile and valuable compound in the field of medicinal chemistry.

InChI:InChI=1/C12H14BrNO/c13-11-6-4-5-10(9-11)12(15)14-7-2-1-3-8-14/h4-6,9H,1-3,7-8H2

Upstream product

• 110-89-4 piperidine 
• 3132-99-8 m-bromobenzoic aldehyde 
• 1711-09-7 3-bromobenzoyl chloride 
• 591-18-4 1-Bromo-3-iodobenzene 
• 201230-82-2 carbon monoxide 
• 15852-73-0 (3-Bromophenyl)methanol 
• 585-76-2 m-bromobenzoic acid 

Downstream Products

• 1616609-87-0 (3-(benzo[d][1,3]dioxol-5-yl)phenyl)(piperidin-1-yl)methanone 
• 1073353-62-4 piperidin-1-yl-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone 
• 1432450-92-4 (3-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-quinazolin-6-yl)phenyl)(piperidin-1-yl)methanone 

Relevant articles and documents

Amidation of Aldehydes with Amines under Mild Conditions Using Metal-Organic Framework Derived NiO@Ni Mott-Schottky Catalyst

Here we report a facile method for the synthesis of nickel oxide-nickel (NiO@Ni) Mott-Schottky catalyst employing metal-organic framework (MOF) as the precursor. A direct amidation protocol of aldehydes with amines has been optimized under mild conditions using NiO@Ni Mott-Schottky catalyst and it shows far better catalytic activity than the NiO?Ni nanoparticles prepared from simple Ni2+ salt under similar reaction conditions. The heterogeneous catalyst is robust, recyclable and efficient to provide comparable yield to costly ligand-based homogeneous Ni catalysts. The scope of the reaction protocol has been explored with variably substituted substrates. The reaction initiates by homolytic cleavage of peroxide and proceeds through radical mechanism.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Towards a sustainable synthesis of amides: chemoselective palladium-catalysed aminocarbonylation of aryl iodides in deep eutectic solvents

A palladium-catalysed aminocarbonylation of (hetero)aryl iodides has, for the first time, been accomplished in deep eutectic solvents as environmentally benign and recyclable media, under mild conditions. The reactions proceeded with a good substrate scope, and a variety of amides have been synthesized in yields up to 98%.