59508-55-3Relevant academic research and scientific papers
Cu/Ag-Cocatalyzed Aerobic Oxidative Amination and CuCl2-Mediated Aerobic Oxidative Chloroamination of Maleimides
An, Yu-Long,Zhang, He-Hui,Yang, Zhen-Hua,Lin, Long,Zhao, Sheng-Yin
, p. 5405 - 5414 (2016/11/22)
An efficient Cu(OAc)2/Ag2CO3-cocatalyzed approach for the synthesis of 3-aminomaleimides and 3-amino-4-indolylmaleimides has been developed with satisfactory yields. A series of primary and secondary amines are compatible with this reaction. In addition, treatment of maleimides with primary amines using 1 equiv. of CuCl2leads to the formation of chloroamination products such as 3-amino-4-chloromaleimides by a radical-type mechanism.
Preparation method of 3-amino-N-substituted maleimide compound
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Paragraph 0023; 0069; 0070, (2018/02/04)
The invention relates to a preparation method of a 3-amino-N-substituted maleimide compound. The preparation method is characterized in that the 3-amino-N-substituted maleimide compound has the structural formula shown in the description, in which R1 is phenyl or benzyl and NR2R3 is pyrrolidinyl, morpholinyl, benzylamino or dimethylamino. The preparation method comprises the following steps: adding N-substituted maleimide, an amine compound and a catalyst into a solvent, heating to 25-140 DEG C, enabling reaction for 1-12 hours and purifying to obtain the 3-amino-N-substituted maleimide compound. The 3-amino-N-substituted maleimide compound prepared by the preparation method provided by the invention is simple in reaction operation, relatively high in yield, short in reaction route, less in generation of waste gas, waste liquid and waste solid and easy to achieve industrial production.
