7685-88-3Relevant academic research and scientific papers
Stereoselective Synthesis of 2-Alkylamino-N-(2'-alhylphenyl)succinimide Conformers
Kishikawa, Keiki,Tsuru, Isao,Kohmoto, Shigeo,Yamamoto, Makoto,Yamada, Kazutoshi
, p. 1605 - 1606 (1994)
Isolable conformers of 2-alkylamino-N-(2'-alkylphenyl)succinimide were stereoselectively synthesised by amination of N-(2'-alkylphenyl)maleimides.The rotational barrier and the α-methylation of them were investigated.
Chemoselective, accelerated and stereoselective aza-Michael addition of amines to N-phenylmaleimide by using TMEDA based receptors
Bi, Yuefeng,Bailly, Laetitia,Marsais, Francis,Levacher, Vincent,Papamicael, Cyril,Dupas, Georges
, p. 3703 - 3706 (2004)
An aza-Michael addition between a maleimide and amines is described in which the presence of simple amine receptors (TMEDA or trans-TMCDA) promote the chemoselectivity of the reaction (respectively, 1,2- and 1,4-addition). Additionally, both receptors are able to accelerate the reaction. Stoichiometries of complexes between receptors and amines were determined by 1H NMR dilution experiments while enantiomeric excesses were observed on 1,4-adducts by using (1R,2R)-TMCDA.
Cu/Ag-Cocatalyzed Aerobic Oxidative Amination and CuCl2-Mediated Aerobic Oxidative Chloroamination of Maleimides
An, Yu-Long,Zhang, He-Hui,Yang, Zhen-Hua,Lin, Long,Zhao, Sheng-Yin
, p. 5405 - 5414 (2016/11/22)
An efficient Cu(OAc)2/Ag2CO3-cocatalyzed approach for the synthesis of 3-aminomaleimides and 3-amino-4-indolylmaleimides has been developed with satisfactory yields. A series of primary and secondary amines are compatible with this reaction. In addition, treatment of maleimides with primary amines using 1 equiv. of CuCl2leads to the formation of chloroamination products such as 3-amino-4-chloromaleimides by a radical-type mechanism.
