59511-72-7

Upstream product

• 62634-84-8 3-amino-2-oxoazetidine 
• 501-53-1 benzyl chloroformate 
• 133995-87-6 (3S)-3-[[(Phenylmethoxy)carbonyl] amino]-1-hydroxy-2-azetidinone 
• 7705-07-9 titanium(III) chloride 
• 18635-43-3 2-(S)-benzyloxycarbonylamino-3-aminopropionic acid 
• 29880-22-6 N-benzyloxy-carbonyl-DL-asparagine 
• 94459-08-2 3-<(benzyloxycarbonyl)amino>-1-(2,4-dimethoxybenzyl)-2-azetidinone 
• 87568-46-5 3-(((benzyloxy)carbonyl)amino)-1-(p-methoxyphenyl)azetidin-2-one 

Downstream Products

• 741629-02-7 (S)-N-(1-Imidazolylsulfonyl)-2-oxo-3-[[(phenylmethoxy) carbonyl]amino]-1-azetidinecarboxamide 
• 84791-03-7 (S)-[1-[[[(4-Methylphenyl)sulfonyl]amino]-carbonyl]-2-oxo-3-azetidinyl]carbamic acid, phenylmethyl ester, triethylammonium salt 
• 80082-84-4 (3S)-(benzyloxycarbonyl)amino-2-azetidine-1-sulfonic acid, potassium salt 
• 114903-84-3 (S)-[1-[[[[(2-cyano-4,5-dihydroxyphenyl)amino]sulfonyl]amino]carbonyl]-2-oxo-3-azetidinyl]carbamic acid, phenylmethyl ester 
• 123981-17-9 (S)-[1-[[[[3-[[(1,4-Dihydro-5-hydroxy-4-oxo-2-pyridinyl)carbonyl]amino]tetrahydro-2-oxo-1(2H)-pyrimidinyl]sulfonyl]amino]carbonyl]-2-oxo-3-azetidinyl]carbamic acid, phenylmethyl ester 

Relevant academic research and scientific papers

Selective sodium channel regulator as well as preparation and application thereof

The invention provides a compound serving as a selective sodium channel regulator and a synthesis and use method, and particularly provides a compound shown as a formula (I), a preparation method of the compound and application of the compound serving as the selective sodium channel regulator. The compounds exhibit excellent activity as a regulator of sodium channels.

Ruthenium Catalyzed Oxidation of 3-Amino-β-Lactams

3-Aminoazetidin-2-ones were converted into the corresponding 4-acetoxy derivatives by treatment with AcOOH and ruthenium on carbon as catalyst.

2-OXO-1-AZETIDINESULFONIC ACID SALTS

Antibacterial activity is exhibited by beta-lactams having a sulfonic acid salt substituent in the 1-position and an amino or acylamino substituent in the 3-position.

N-Acyloxy monocyclic β-lactams

Process for N-acyloxy or sulfooxy 2-azetidinones comprising O-acylation of a β-hydroxy or β-halo hydroxamic acid, and cyclizing the O-acylhydroxamate with TPP-CCl4 -TEA or with TPP-dialkylazodicarboxylate to the N-acyloxy-2-azetidinone. Solvoly

2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines

Antibacterial activity is exhibited by β-lactams having a STR1 substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur, and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5

A Convenient Synthesis of 4-Unsubstituted β-Lactams

The reaction of lithium ester enolates with N-(cyanomethyl)amines affords 4-unsubstituted β-lactams in good yields, see eq 1.The N-1 substituent can be varied widely, as can the C-3 substituents, which can be H, alkyl, SPh, NH2, or NHCOR.The preparation o

2-Oxo-1-[(acylamino)sulfonyl]azetidines

Antibacterial activity is exhibited by β-lactams having an --SO2 --NH--C--R substituent in the 1-position and an acylamino substituent in the 3-position wherein R is alkyl, phenyl, substituted phenyl, phenylalkyl, (substituted phenyl)alkyl, alk

Desulfurization of penicillins to prepare azetidinones

A process for the Raney nickel desulfurization of penicillins is described. In the process of the invention, amino penicillanic acid or derivatives thereof are reacted with Raney nickel under controlled conditions of temperature and time to yield azetidinones which are useful as intermediates for the synthesis of monocyclic beta-lactam antibiotics.

Synthesis of β-lactam antibiotics by the sulfeno-cycloamination

A novel efficient beta -lactam synthesis was achieved by two successive processes (sulfeno-cycloamination), addition of phenysulfenyl chloride to alpha , beta -unsaturated amides followed by base treatment. Key synthetic intermediates of monobactams and nocardicin derivatives were obtained via this method. construction of the 1-carbapenam ring system by the sulfenocycloamination is also described.