59529-41-8Relevant academic research and scientific papers
Synthesis and structure of 1,12-bis-(N-naphthalamido)-4,9-bis-(2,4,6-trimethylbenzenesulfonyl)-4,9-diaza- dodecane
Wardell, Solange M. S. V.,Lin, Paul Kong Thoo
, p. 683 - 687 (1998)
1,12-Bis-(N-naphthalamido)-4,9-bis-(2,4,6-trimethylbenzenesulfonyl)-4,9- diaza-dodecane 1 was obtained from 1,8-naphthalic anhydride on successive reactions with 3-aminopropanol, 4-methylbenzenesulfonyl chloride and 1,4-bis-(2,4,6-trimethylbenzenesulfonamido)butane. The molecular structure of 1 was investigated by X-ray crystallography, NMR, and mass spectrometry. The molecule crystallizes in the triclinic space group, P1. The cell parameters are a = 8.1548(12), b = 15.878(3), c = 18.005(3) A, α = 97.685(10), β = 93.260(15), and γ = 101.754(11)°. The asymmetric unit consists of the halves of two independent molecules, with Z = 2.
A novel paa derivative with enhanced drug efficacy in pancreatic cancer cell lines
Alsuraifi, Ali,Lin, Paul Kong Thoo,Curtis, Anthony,Lamprou, Dimitrios A.,Hoskins, Clare
, (2018)
Nanoparticles have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery systems and
The synthesis and in vitro cytotoxic studies of novel bus-naphthalimidopropyl polyamine derivatives
Lin, Paul Kong Thoo,Pavlov, Valentin A.
, p. 1609 - 1612 (2000)
Bis-naphthalimidopropyl putrescine (BNIPPut), spermidine (BNISpd), spermine (BNISpm) and oxa-putrescine (BNIPOPut) were synthesised and their growth-inhibitory properties characterised. All these compounds except for BNIPOPut, showed high in vitro cytotox
Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells
Kopsida, Maria,Barron, Gemma A.,Bermano, Giovanna,Kong Thoo Lin, Paul,Goua, Marie
, p. 9780 - 9789 (2016/10/31)
Bisnaphthalimidopropyl (BNIP) derivatives are a family of compounds that exert anti-cancer activities in vitro and, according to previous studies, variations in the linker sequence have increased their DNA binding and cytotoxic activities. By modifying th
Synthesis, cytotoxicity and DNA-binding of novel bisnaphthalimidopropyl derivatives in breast cancer MDA-MB-231 cells
Barron, Gemma A.,Bermano, Giovanna,Gordon, Amanda,Kong Thoo Lin, Paul
experimental part, p. 1430 - 1437 (2010/06/16)
New naphthalimidopropyl, bisphthalimidopropyl and bisnaphthalimidopropyl (BNIP) derivatives were synthesised and characterised. Their interactions with Calf Thymus DNA were studied by UV spectrophotometric analysis and a competitive Ethidium bromide displacement assay. Cytotoxicity was determined by MTT assay in a breast cell system (MDA-MB-231 and MCF-10A cells). All BNIPs exhibited strong DNA-binding properties and cytotoxic activity with IC50 values in the range of 0.83-12.68?μM (24 and 48?h treatment). In addition, the uptake of BNIP derivatives within cancer cells was not via utilisation of the MGBG polyamine transporter. Put together the results confirm that the presence of the bisnaphthalimidopropyl and alkyl linker functionality are crucial for exerting DNA-binding and cytotoxic properties, hence demonstrating promise in their further development as potential anti cancer agents.
BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY
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Page/Page column 7-8; 9, (2009/04/24)
The bisnaphthalimidopropyl derivatives with anti-parasitic and anti-cancer activity. Bisnaphthalimidopropyl derivatives (A) BNIPPut, BNIPDapen, BNIPDhex, BNIPDahep, BNIPDaoct, BNIPDanon, BNTPDadec, BNIPDadod, BNPDpta, BNIPDeta were synthesized in yields r
The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum
Oliveira, Joao,Ralton, Lynda,Tavares, Joana,Codeiro-da-Silva, Anabela,Bestwick, Charles S.,McPherson, Anne,Thoo Lin, Paul Kong
, p. 541 - 545 (2008/03/15)
Bisnaphthalimidopropyl derivatives (BNIPSpd, BNIPDaoct, BNIPDanon, BNIPDadec, BNIPDpta and BNIPDeta) were synthesised in yields ranging from 50% to 70% and their cytotoxicity against colon cancer cells (Caco-2) and the parasite Leishmania infantum determi
Photoinduced electron transfer in covalently linked 1,8-naphthalimide/viologen systems
Le, Thao P.,Rogers, Joy E.,Kelly, Lisa A.
, p. 6778 - 6785 (2007/10/03)
A series of polymethylene-linked 1,8-naphthalimide/viologen diads has been synthesized. The number of intervening methylenes was varied from 2 to 6. For comparison, a series of W-alkylpyridiniumyl-1,8-naphthalimide "parent" compounds was prepared and phot
