59531-53-2

Basic information

• Product Name: 12α-hydroxyandrosta-1,4-dien-3,17-dione
• Synonyms: 12α-hydroxyandrosta-1,4-dien-3,17-dione
• CAS NO: 59531-53-2
• Molecular Weight: 300.398
• Mol File: 59531-53-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 12α-hydroxyandrosta-1,4-dien-3,17-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 12α-hydroxyandrosta-1,4-dien-3,17-dione(59531-53-2)
• EPA Substance Registry System: 12α-hydroxyandrosta-1,4-dien-3,17-dione(59531-53-2)

Safety Data

• Hazardous Substances Data: 59531-53-2(Hazardous Substances Data)

Upstream product

• 28840-96-2 12β-hydroxy-1,4-androstadiene-3,17-dione 
• 83-44-3 Deoxycholic acid 
• 302-95-4 sodium cholate 

Downstream Products

• 209972-88-3 3-benzyloxy-17β-(t-butyldimethylsilyloxy)-12,12-ethylenedioxyestra-1,3,5(10)-triene 
• 209972-92-9 3-benzyloxy-12,12-ethylenedioxyestra-1,3,5(10)-trien-17β-ol 

Relevant articles and documents

DEOXYCHOLIC ACID DEGRADATION BY A PSEUDOMONAS SP: PHENOLIC AND NEUTRAL PRODUCTS

The microbial degradation of deoxycholic acid by Pseudomonas sp.MR108 was studied, and four products were isolated.Evidence is presented that one is the phenol 3,12β-dihydroxy-9,10-secoandrosta-1,3,5(10)-trien-9,17-dione (11) and that the other three are the neutral compounds 3aαH-4α--5α-hydroxy-7aβ-methyl-hexahydro-1-indanone-δ-lactone (12), 12β-hydroxyandrosta-1,4-dien-3,17-dione (10), and 12α-hydroxyandrosta-1,4-dien-3,17-dione (7).

MICROBIAL DEGRADATION OF DEOXYCHOLIC ACID BY PSEUDOMONAS sp. NCIB 10590. CHARACTERISATION OF PRODUCTS AND A POSTULATED PATHWAY

Minor products in the microbial degradation of deoxychlolic acid are characterised and a metabolic pathway proposed.In a previous publocation we reported the transformation of deoxycholic acid 1 by Pseudomonas sp.NCIB 10590, in a mineral salts medium, to a mixture of neutral and acidic steroids.The major neutral product, 12β-hydroxyandrosta-1,4-dien-3,17-dione 2 and the major acidic product 12α-hydroxypregna-1,4-dien-3-one-20-carboxylic acid 9 were identified.We now report the structures of the minor products and propose a metabolic pathway.