59548-24-2

Upstream product

• 1145-01-3 3,5-Diphenylpyrazole 
• 100-19-6 (4-nitrophenyl)ethanone 
• 555-16-8 4-nitrobenzaldehdye 
• 25870-67-1 1,3-bis(4-nitrophenyl)prop-2-en-1-one 
• 102692-42-2 (E)-3-(4-nitrophenyl)-1-(4-nitrophenyl)-2-propen-1-one 
• 13586-91-9 1,3-bis-(4-nitrophenyl)propane-1,3-dione 

Downstream Products

• 102183-30-2 1,2,5-tri-(4-nitrophenyl)-1H-pyrazole 
• 1313744-14-7 (2S,2'S)-N,N'-(4,4'-(1H-pyrazole-3,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide) 
• 1313751-13-1 (2S,2'S)-tert-butyl 2,2'-N,N'-(4,4'-(1H-pyrazole-3,5-diyl)bis(4,1-phenylene))bis(azanediyl)bis(oxomethylene)dipyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Transition-Metal-Free N-Arylation of Pyrazoles with Diaryliodonium Salts

A new synthetic method was developed for the N-arylation of pyrazoles using diaryliodonium salts. The transformation does not require any transition-metal catalyst and provides the desired N-arylpyrazoles rapidly under mild reaction condition in the presence of aqueous ammonia solution as a mild base without the use of inert atmosphere. The chemoselectivity of unsymmetric diaryliodonium salts was also explored with large number of examples.

One-pot synthesis of 3,5-diphenyl-1h-pyrazoles from chalcones and hydrazine under mechanochemical ball milling

A highly efficient and environmentally friendly method has been developed for facile synthesis of 3,5-diphenyl-1H-pyrazoles under mechanochemical ball-milling conditions. The advantages of short reaction time, high efficiency, no separation of in situ generated intermediate, using cheap sodium persulfate as the oxidant, together with very simple work-up procedure, make this one-pot and solvent-free protocol a green and powerful alternative to traditional methods for the synthesis of these kinds of compounds.

HCV NS5A replication complex inhibitors. Part 3

In a recent disclosure,1 we described the discovery of dimeric, prolinamide-based NS5A replication complex inhibitors exhibiting excellent potency towards an HCV genotype 1b replicon. That disclosure dealt with the SAR exploration of the peripheral region of our lead chemotype, and herein is described the SAR uncovered from a complementary effort that focused on the central core region. From this effort, the contribution of the core region to the overall topology of the pharmacophore, primarily vector orientation and planarity, was determined, with a set of analogs exhibiting 50 in a genotype 1b replicon assay.

HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein

New one step synthesis of 3,5-disubstituted pyrazoles under microwave irradiation and classical heating

(Chemical Equation Presented) A convenient one pot procedure for the synthesis of 3,5-disubstituted pyrazoles by condensation of chalcones, hydrazine hydrate and sulfur in ethanol under microwave irradiation and conventional heating method is reported. The hydrogen sulfide is produced during the reaction. The pyrazoles are obtained in good yields and excellent state of purity. The structures of new compounds were confirmed by IR, 1H, and 13C NMR, MS and elemental analysis.