59549-51-8

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-2-CHLORO-4-(METHYLTHIO)PYRIMIDINE is used as a building block for the synthesis of various biologically active compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 5-BROMO-2-CHLORO-4-(METHYLTHIO)PYRIMIDINE serves as a key component in the creation of agrochemicals, such as pesticides and herbicides, due to its ability to be incorporated into molecules with specific biological activities.
Used as a Reagent in Organic Synthesis:
5-BROMO-2-CHLORO-4-(METHYLTHIO)PYRIMIDINE is utilized as a reagent to introduce the 2-chloro-4-(methylthio)pyrimidine group into other molecules, facilitating the synthesis of diverse organic compounds with specific properties and applications.
Safety Note:
Due to its moderate toxicity, 5-BROMO-2-CHLORO-4-(METHYLTHIO)PYRIMIDINE should be handled with care in laboratory settings to ensure the safety of researchers and the environment.

InChI:InChI=1/C5H4BrClN2S/c1-10-4-3(6)2-8-5(7)9-4/h2H,1H3

Upstream product

• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 917896-40-3 2-methyl-4-methylsulfanyl-5-(4-trifluoromethyl-phenyl)-pyrimidine 
• 1403865-31-5 5-bromo-N-(1-methylcyclopropyl)-4-(methylthio)pyrimidin-2-amine 
• 1220417-45-7 (5-bromo-4-methylsulfanyl-pyrimidin-2-yl)-(3-chloro-4-fluorophenyl)-amine 
• 1034358-66-1 N-(5-bromo-4-methylsulphanylpyrimidin-2-yl)-N'-pyrimidin-2-yl-benzene-1,4-diamine 

Relevant academic research and scientific papers

JNK inhibitor as well as pharmaceutical composition and application thereof

The invention provides a compound represented by a formula (I), racemates, stereoisomers, tautomers, isotope markers, solvates, polymorphic substances, nitrogen oxides, or pharmaceutically acceptablesalts thereof, and application as a JNK inhibitor. The invention also provides a preparation method of the compound shown in the formula (I), a pharmaceutical composition containing the compound shownin the formula (I), and application of the compound shown in the formula (I) to preparation of a medicine, and the medicine is used for treating diseases which can be treated by inhibiting the activity of JNK.

Substituted sulphoximines as Tie2 inhibitors and salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same and uses of the same

The invention relates to substituted sulphoximines according to the general formula (I): in which A, E, G, X, R1, R2, R3, R4, R5, R6, R7, R8, m, p, q, are given in the

NOVEL HETARYL-PHENYLENEDIAMINE-PYRIMIDINES AS PROTEIN KINASE INHIBITORS

The invention relates to novel hetaryl-phenylenediamine-pyrimidines and to their structurally related oxygen and sulphur analogues of the general formula I, processes for their preparation, and their use as medicaments.

SULFOXIMINE-SUBSTITUTED PYRIMIDINES , THEIR PREPARATION AND USE AS DRUGS

The invention relates to sulfoximine-substituted pyrimidines of the general Formula (I) processes for the preparation thereof and their use as kinase inhibitors for treating for example cancer or inflammation.

Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs

The invention relates to sulfoximine-substituted pyrimidines of the general formula I processes for the preparation thereof and their use as drugs.

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABAB receptors is presented.