36082-50-5

Basic information

• Product Name: 5-Bromo-2,4-dichloropyrimidine
• Synonyms: BUTTPARK 48\06-22;5-BROMO-2,4-DICHLOROPYRIMIDINE;2,4-DICHLORO-5-BROMO PYRIMIDINE;TIMTEC-BB SBB003301;5-Bromo-2,4-Dichloropyridimidine;5-BROMO-2,4-DICHLOROPYRIMIDINE 99%;5-Bromo-2,4-dichloropyrimidine ,97%;5-Bromo-2,4-dichloropyrimidine,98%
• CAS NO: 36082-50-5
• Molecular Formula: C₄HBrCl₂N₂
• Molecular Weight: 227.87414
• EINECS: -0
• Product Categories: Pyrimidine Series;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrimidine;Halogenated;Organohalides;Nucleotides and Nucleosides;Aromatics Compounds;Bases & Related Reagents;Nucleotides;Aromatics;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Building Blocks;C4 to C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 36082-50-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 29-30 °C(lit.)
• Boiling Point: 128 °C15 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to light yellow/Liquid or Low Melting Solid
• Density: 1.781 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: n20/D 1.603(lit.)
• Storage Temp.: Keep Cold
• Solubility: Chloroform (Slightly), Ether (Slightly), Ethyl Acetate (Slightly), Toluene (Slig
• PKA: -4.26±0.29(Predicted)
• BRN: 124441
• CAS DataBase Reference: 5-Bromo-2,4-dichloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2,4-dichloropyrimidine(36082-50-5)
• EPA Substance Registry System: 5-Bromo-2,4-dichloropyrimidine(36082-50-5)

Safety Data

• Hazard Codes: T,C
• Statements: 23/24/25-34-43
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3263 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 36082-50-5(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Uses

Different sources of media describe the Uses of 36082-50-5 differently. You can refer to the following data:
1. Starting material for the synthesis of trisubstituted pyrimidines via a combination of nucleophilic substitution and palladium-catalyzed aryl cross-coupling.1
2. 5-Bromo-2,4-dichloropyrimidine may be employed as starting reagent for the synthesis of positive allosteric modulators for GABAB receptors (drug-like class of compounds) and pyridinepyrimidine analogs.

General Description

5-Bromo-2,4-dichloropyrimidine is a halogenoprimidine. It has been reported as an intermediate during the synthesis of 2,4-di-t-butoxy-5-bromopyrimidine and 2,4-di-t-butoxy-5-pyrimidineboronic acid.

InChI:InChI=1/C4HBrCl2N2/c5-2-1-8-4(7)9-3(2)6/h1H

Synthetic route

5-bromouracil (51-20-7) → 2,4-dichloro-5-bromopyrimidine (36082-50-5)

Conditions	Yield
With phosphorus pentachloride In 1,1,2-trichloroethane Reagent/catalyst; Solvent; Reflux;	99.5%
With N,N-dimethyl-aniline; trichlorophosphate at 120 - 130℃; for 1.33333h;	96.6%
With phosgene; Tributylphosphine oxide at -5 - 125℃; for 1.83333h; Inert atmosphere;	89.7%

2,4-dihydroxy-5-bromopyrimidine (51-20-7) → 2,4-dichloro-5-bromopyrimidine (36082-50-5)

Conditions	Yield
With pyridine; trichlorophosphate at 160℃; for 2h; Autoclave; neat (no solvent);	91%
With dmap; thionyl chloride; bis(trichloromethyl) carbonate for 12.5h; Reflux; Green chemistry;	90%
With phosphorus pentachloride; trichlorophosphate

5-bromouracil (51-20-7) + phosphorus pentachloride (10026-13-8, 874483-75-7) + trichlorophosphate (10025-87-3, 12599-09-6, 63736-95-8) → 2,4-dichloro-5-bromopyrimidine (36082-50-5)

5-bromo-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (113138-12-8) → 2,4-dichloro-5-bromopyrimidine (36082-50-5)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; trichlorophosphate at 90℃;

2,4-dichloro-5-bromopyrimidine (36082-50-5) → 4-amino-5-bromo-2-chloropyrimidine (205672-25-9)

Conditions	Yield
With ammonia In methanol at 20℃;	100%
With ammonium hydroxide In tetrahydrofuran at 20℃; for 12h;	100%
With ammonium hydroxide In tetrahydrofuran; water at 20℃; for 1.5h;	100%

2,4-dichloro-5-bromopyrimidine (36082-50-5) → 5-bromo-2-chloro-pyrimidin-4(3H)-one (844843-37-4)

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 6h; Cooling;	86%
Stage #1: 2,4-dichloro-5-bromopyrimidine With sodium hydroxide In tetrahydrofuran at 20℃; for 3h; Stage #2: With hydrogenchloride In tetrahydrofuran	64%
Stage #1: 2,4-dichloro-5-bromopyrimidine With sodium hydroxide In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere;	64%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + (2-aminophenyl)dimethyl phosphorus oxide (1197953-47-1) → (2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide (1407520-11-9)

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate In N,N-dimethyl-formamide at 65℃; for 8h;	72%
With potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate In N,N-dimethyl-formamide at 65℃; for 7h;	66%
With tetrabutylammonium hydrogensulfate; potassium carbonate In N,N-dimethyl-formamide at 65℃; for 7h;	66%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h;	2.96 g

2,4-dichloro-5-bromopyrimidine (36082-50-5) + N-Boc-1,3-diaminopropane (75178-96-0) → (3-((5-bromo-2-chloropyrimidin-4-yl)amino)propyl)carbamic acid tert-butyl ester (1046784-89-7)

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 3.5h;	100%
With triethylamine In acetonitrile at 20℃; for 0.5h;	41%
With triethylamine In acetonitrile at 0 - 20℃;
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol regioselective reaction;
With potassium carbonate In isopropyl alcohol at 80℃; for 24h;

2,4-dichloro-5-bromopyrimidine (36082-50-5) + (3-aminophenyl)carbamic acid tert-butyl ester (68621-88-5) → tert-butyl (3-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)carbamate (1202760-30-2)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	99%
With potassium carbonate In N,N-dimethyl-formamide at 21℃; for 16h; Inert atmosphere;	98%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;	98%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + methylamine (74-89-5) → 5-bromo-2-chloro-N-methyl-pyrimidin-4-amine (205672-24-8)

Conditions	Yield
In methanol at 0 - 20℃; for 3.66667h;	100%
In methanol; water Cooling with ice;	88%
In methanol; ethanol at 0 - 20℃; for 3h;	88%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → tert-butyl 4-((5-bromo-2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate (954221-10-4)

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 0.5h;	82%
With trimethylamine In acetonitrile at 20℃; for 2h;	82%
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃;	67%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + benzyl alcohol (100-51-6) → 2,4-bis(benzyloxy)-5-bromopyrimidine (41244-53-5)

Conditions	Yield
With sodium hydride In toluene at 20 - 25℃; for 12h;	93%
With sodium hydride In toluene at 20℃; for 18h;	91%
With sodium hydride 1.) toluene, 50 deg C, 2.) toluene, 25 deg C, overnight; Yield given. Multistep reaction;
With sodium hydride

2,4-dichloro-5-bromopyrimidine (36082-50-5) + 4-Aminobutanol (13325-10-5) → 4-((5-bromo-2-chloropyrimidin-4-yl)amino)butan-1-ol (477593-33-2)

Conditions	Yield
With triethylamine In acetonitrile at 0 - 20℃; for 16h;	98%
With triethylamine In acetonitrile at 0 - 20℃; for 16h;	98%
With triethylamine In butan-1-ol at 125℃; for 1h; Inert atmosphere; Microwave irradiation;	77%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 0.333333h; Microwave irradiation;

2,4-dichloro-5-bromopyrimidine (36082-50-5) + (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine (147081-44-5) → (S)-tert-butyl 3-(5-bromo-2-chloropyrimidin-4-ylamino)pyrrolidine-1-carboxylate (1146159-74-1)

Conditions	Yield
With triethylamine In 1,4-dioxane at 10 - 20℃; for 20h;	67%
With potassium carbonate In N,N-dimethyl-formamide
With potassium carbonate In acetonitrile at 0 - 20℃;
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 8h;
With potassium carbonate In acetonitrile at 20℃;

2,4-dichloro-5-bromopyrimidine (36082-50-5) → 1-(5-bromo-2-chloropyrimidine-4-yl)hydrazine (1021268-16-5)

Conditions	Yield
With hydrazine hydrate In ethanol for 12h; Reflux; Inert atmosphere;	100%
With hydrazine hydrate In methanol at 20℃; for 1h; Cooling with ice;	87%
With hydrazine hydrate In ethanol at 5 - 20℃; for 1h;	75%
With hydrazine hydrate; triethylamine In ethanol at 20℃; for 1h; Cooling with ice;

2,4-dichloro-5-bromopyrimidine (36082-50-5) + cyclohexylamine (108-91-8) → 5-bromo-2-chloro-N-cyclohexylpyrimidin-4-amine (864655-05-0)

Conditions	Yield
In tetrahydrofuran at 50℃; for 12h;	95%
With diisopropylamine In 1,4-dioxane at 20℃; for 6h;	63%
With sodium hydrogencarbonate In methanol at 20℃; for 6h;	54%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + (R,R)-2,3-butandiol (24347-58-8) → (2R,3R)-3-[(5-bromo-2-chloropyrimidin-4-yl)oxy]butan-2-ol (851008-29-2)

Conditions	Yield
Stage #1: (R,R)-2,3-butandiol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.166667h; Stage #2: 2,4-dichloro-5-bromopyrimidine In tetrahydrofuran at 20℃; for 12h;	81%
Stage #1: (R,R)-2,3-butandiol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.166667h; Stage #2: 2,4-dichloro-5-bromopyrimidine In tetrahydrofuran at 0 - 20℃; for 12h;	81%
Stage #1: (R,R)-2,3-butandiol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h; Stage #2: 2,4-dichloro-5-bromopyrimidine In tetrahydrofuran at 0 - 20℃; for 12h;	57%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + N-{3-[(3-cyano-propyl)-methanesulfonyl-amino]-phenyl}-acetamide (936920-11-5) → N-(3-{[4-(5-bromo-2-chloro-pyrimidin-4-ylamino)-butyl]-methanesulfonyl-amino}-phenyl)-acetamide

Conditions	Yield
Stage #1: 2,4-dichloro-5-bromopyrimidine; N-{3-[(3-cyano-propyl)-methanesulfonyl-amino]-phenyl}-acetamide With hydrogenchloride; hydrogen; platinum(IV) oxide In ethanol; water at 20℃; under 760.051 Torr; for 5h; Stage #2: 2,4-dichloro-5-bromopyrimidine With triethylamine In acetonitrile at 20℃; for 16h;	43%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + 2,2-dimethoxyethylamine (22483-09-6) → 5-bromo-2-chloro-N-(2,2-dimethoxyethyl)pyrimidin-4-amine

Conditions	Yield
With triethylamine In ethanol at 20℃; for 24h;	83%
With triethylamine In ethanol at 0 - 20℃; for 12h;	77%
Stage #1: 2,4-dichloro-5-bromopyrimidine; 2,2-dimethoxyethylamine In ethanol at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With triethylamine In ethanol Inert atmosphere;	64%
With triethylamine In ethanol at 0 - 20℃; for 16.25h;

2,4-dichloro-5-bromopyrimidine (36082-50-5) + D-alanine methyl ester hydrochloride (14316-06-4) → methyl N-(5-bromo-2-chloropyrimidin-4-yl)-D-alaninate (851008-31-6)

Conditions	Yield
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; for 48h;	86%
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 48h;	86%
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; for 48h;	86%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + meta-nitrophenol (554-84-7) → 5-bromo-2-chloro-4-(3-nitrophenoxy)pyrimidine

Conditions	Yield
Stage #1: meta-nitrophenol With sodium hydride In dimethyl sulfoxide; N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 2,4-dichloro-5-bromopyrimidine In dimethyl sulfoxide; N,N-dimethyl-formamide at 20℃;	93%
With potassium carbonate In N,N-dimethyl-formamide
With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 20℃;

2,4-dichloro-5-bromopyrimidine (36082-50-5) + 4-fluoroaniline (371-40-4) → 5-bromo-2-chloro-4-[(4-fluorophenyl)amino]-pyrimidine (280582-07-2)

Conditions	Yield
With sodium acetate In tetrahydrofuran; water at 20℃; for 18h;	90%
With potassium carbonate In water; isopropyl alcohol at 20℃; for 18h;	90%
With sodium carbonate In ethanol at 20℃; for 16h;

2,4-dichloro-5-bromopyrimidine (36082-50-5) + sodium methylate (124-41-4) → 5-bromo-2-chloro-4-methoxypyrimidine (57054-92-9)

Conditions	Yield
With methanol at 20℃; for 4h;	93%
In methanol at 20℃; for 4h; Cooling with ice;	93%
In methanol at 20℃; for 12h;	90%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + tert-butyl 4-(aminomethyl)piperidine-1-carboxylate (144222-22-0) → 4-[(5-bromo-2-chloro-pyrimidin-4-ylamino)methyl]-piperidine-1-carboxylic acid tert-butyl ester (1289114-86-8)

Conditions	Yield
With trimethylamine In acetonitrile at 20℃; for 2h;	92%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 50℃; for 2h; Inert atmosphere;	75%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 0.333333h; Microwave irradiation;

2,4-dichloro-5-bromopyrimidine (36082-50-5) + 4-methoxy-aniline (104-94-9) → 5-bromo-2-chloro-N-(4-methoxyphenyl)pyrimidin-4-amine

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 100℃;	72%
With potassium carbonate In water; isopropyl alcohol at 20℃;	51.4%
Stage #1: 2,4-dichloro-5-bromopyrimidine; 4-methoxy-aniline In isopropyl alcohol at 20℃; Stage #2: With potassium carbonate In water at 20℃;	51.4%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + 5-aminobenzimidazole (934-22-5) → (1H-Benzoimidazol-5-yl)-(5-bromo-2-chloro-pyrimidin-4-yl)-amine (852357-08-5)

Conditions	Yield
With sodium carbonate In ethanol at 20℃; for 24h;	93%
With sodium carbonate In ethanol at 20℃; for 16h;

2,4-dichloro-5-bromopyrimidine (36082-50-5) + 2,2-dimethylpropylamine (5813-64-9) → (5-bromo-2-chloropyrimidin-4-yl)-(2,2-dimethylpropyl)amine

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 2h;	70%
With sodium hydrogencarbonate In methanol at 20℃; for 6h;
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 2h;

2,4-dichloro-5-bromopyrimidine (36082-50-5) + sodium thiomethoxide (5188-07-8) → 5-bromo-2-chloro-4-(methylthio)pyrimidine (59549-51-8)

Conditions	Yield
In acetonitrile at 20℃;	82.8%
In acetonitrile at 20℃; for 24h;	70%
In acetonitrile at 20℃; for 24h;	70%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → 2,4-dichloro-5-pyrimidinecarboxaldehyde (871254-61-4)

Conditions	Yield
Stage #1: 2,4-dichloro-5-bromopyrimidine With TurboGrignard In tetrahydrofuran at -78℃; for 2h; Bouveault Aldehyde Synthesis; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78 - -42℃; for 12h;	38%
Stage #1: 2,4-dichloro-5-bromopyrimidine With isopropylmagnesium chloride; lithium chloride In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78 - -35℃; for 4h;	31%
Stage #1: 2,4-dichloro-5-bromopyrimidine With hydrogenchloride In tetrahydrofuran at -78 - 35℃; for 0.5h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78℃; for 2h;	28%

4-morpholinecarboxaldehyde (4394-85-8) + 2,4-dichloro-5-bromopyrimidine (36082-50-5) → 2,4-dichloro-5-pyrimidinecarboxaldehyde (871254-61-4)

Conditions	Yield
Stage #1: 2,4-dichloro-5-bromopyrimidine With TurboGrignard In tetrahydrofuran at -78 - -42℃; for 1.25h; Stage #2: 4-morpholinecarboxaldehyde In tetrahydrofuran at -78 - -42℃; for 3.91667h;	87%
Stage #1: 2,4-dichloro-5-bromopyrimidine With TurboGrignard In tetrahydrofuran at 78℃; for 1h; Stage #2: 4-morpholinecarboxaldehyde In tetrahydrofuran at -78 - -35℃; for 1.5h; Stage #3: With hydrogenchloride; water In tetrahydrofuran at -35℃;	71%

indole (120-72-9) + 2,4-dichloro-5-bromopyrimidine (36082-50-5) → 3-(5-Bromo-2-chloropyrimidin-4-yl)-1H-indole (1356962-87-2)

Conditions	Yield
Stage #1: 2,4-dichloro-5-bromopyrimidine With aluminum (III) chloride In 1,2-dichloro-ethane at 80℃; for 0.5h; Stage #2: indole In 1,2-dichloro-ethane at 80℃; for 18h;	98%
Stage #1: indole With methylmagnesium bromide In tetrahydrofuran; diethyl ether at 0℃; for 0.75h; Inert atmosphere; Stage #2: 2,4-dichloro-5-bromopyrimidine In tetrahydrofuran; diethyl ether at 0 - 60℃; for 2.25h; Inert atmosphere;	75%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + m-bromobenzoic aldehyde (3132-99-8) → (3-bromo-phenyl)-(2,4-dichloro-pyrimidin-5-yl)-methanol (1386399-13-8)

Conditions	Yield
Stage #1: 2,4-dichloro-5-bromopyrimidine With isopropylmagnesium chloride In tetrahydrofuran at -35℃; for 1h; Inert atmosphere; Stage #2: m-bromobenzoic aldehyde In tetrahydrofuran at -35℃; for 2h; Inert atmosphere; Stage #3: With water In tetrahydrofuran Inert atmosphere;	98.8%
Stage #1: 2,4-dichloro-5-bromopyrimidine With isopropylmagnesium chloride In tetrahydrofuran at -35℃; for 1h; Inert atmosphere; Stage #2: m-bromobenzoic aldehyde at -35℃; for 2h;	98.8%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(5-bromo-2-chloropyrimidin-4-yl)piperazine-1-carboxylate (1289198-78-2)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 30℃; for 2h;	89%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 0.333333h; Microwave irradiation;

Upstream product

• 113138-12-8 5-bromo-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 51-20-7 5-bromouracil 
• 10026-13-8 phosphorus pentachloride 
• 10025-87-3 trichlorophosphate 
• 51-20-7 2,4-dihydroxy-5-bromopyrimidine 

Downstream Products

• 19752-61-5 5-bromo-2,4-di(tert-butoxy)pyrimidine 
• 325702-64-5 2-(5-bromo-2-chloro-pyrimidin-4-ylamino)-benzoic acid 
• 870722-92-2 2-chloro-5-bromo-4-phenylpyrimidine 
• 358789-15-8 5-bromo-2-chloro-4-(4-methoxyphenoxy)pyrimidine 
• 1061740-00-8 5-bromo-2-chloro-N-[2-(methyloxy)phenyl]-4-pyrimidinamine 
• 1169699-72-2 (5-bromo-2-chloro-pyrimidin-4-yl)-cyclohexyl-phenyl-amine 
• 1192712-30-3 tert-butyl (1-(5-bromo-2-chloropyrimidin-4-yl)piperidin-4-yl)methylcarbamate 
• 936920-24-0 N-[3-(5-Bromo-2-chloro-pyrimidin-4-yloxy)-propyl]-3-nitro-benzenesulfonamide 
• 477593-60-5 [3-(5-bromo-2-chloro-pyrimidin-4-ylamino)-propyl]-carbamic acid benzyl ester 
• 1033955-63-3 4-(5-bromo-2-chloro-pyrimidin-4-yloxy)-3-chloro-5-methyl-benzonitrile 
• 1039022-18-8 C₁₂H₆BrClFN₃O 
• 1884220-36-3 2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide 

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The invention discloses a preparation method, namely BTC and SOCl, of a chloropolyhydroxyl aza heteroaromatic ring compound as a raw material with a polyhydroxy aza heteroaromatic ring compound as a raw material, and a preparation method thereof. 2 As the double chlorination reagent, a chloropolyhydroxyl aza-aromatic ring compound is produced by chlorination reaction with 4 - dimethylaminopyridine (DMAP) as a catalyst at room temperature to reflux temperature of the reaction, as a catalyst. BTC TC TC TC2 /DMDMAP chlorination system has high efficiency, high selectivity and chlorine substitution on a polyhydroxy nitrogen heterocyclic compound; the system can replace POCl3 , The production of phosphorus-containing wastewater is avoided. Using BTC as a chlorination reagent, the reaction by-product was HCl and CO. 2 . From the aspects of industrial wastewater treatment, environmental protection and the like, the advantages thereof are obvious; SOCl is distilled off after the reaction is ended. 2 The quantity is almost no loss, can be used repeatedly, and reduces the process cost. (by machine translation)

Preparation method for halogenated uracil compounds

The invention discloses a preparation method for halogenated uracil compounds as shown in a formula 2 which is described in the specification. The preparation method comprises a step of subjecting a compound 1 and PCl5 to a chlorination reaction in a solvent. X in the formula is F, Cl, Br or I. The solvent is one or more selected from a group consisting of SOCl2, carbon tetrachloride, 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene and 1,1,2-trichloroethane. The preparation method uses 5-halouracil as a starting material, and is simple in process, high in yield, friendly to environment and suitable for industrial production.