59557-89-0

Usage

Uses

Used in Organic Synthesis:
4-bromo-N,2-dimethylaniline is utilized as a building block in organic synthesis for the creation of various biologically active compounds. Its presence in the synthesis process contributes to the development of new chemical entities with potential applications in different fields.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 4-bromo-N,2-dimethylaniline is employed as a key intermediate in the production of drugs. Its structural attributes make it a valuable component in the synthesis of pharmaceuticals that target specific biological pathways.
Used in Dye and Pigment Production:
4-bromo-N,2-dimethylaniline is used as a precursor in the manufacturing of dyes and pigments. Its chemical properties allow for the creation of colorants that have specific characteristics, such as stability and intensity, which are essential in various industries.
Used in Agrochemicals:
4-bromo-N,2-dimethylaniline also finds application in the production of agrochemicals, where it may contribute to the development of products that enhance crop protection and yield.
Used in Medicinal Chemistry and Pharmacology:
Due to its structural features, 4-bromo-N,2-dimethylaniline may have potential applications in medicinal chemistry and pharmacology. It could be a component in the design of new drugs or in the study of molecular interactions relevant to therapeutic development.
It is crucial to handle 4-bromo-N,2-dimethylaniline with care due to its potential health hazards and environmental risks. Proper management and disposal are necessary to mitigate any adverse effects associated with this chemical compound.

Upstream product

• 611-21-2 N,2-dimethylaniline 
• 67-56-1 methanol 
• 583-75-5 4-Bromo-2-methylaniline 
• 74-88-4 methyl iodide 

Downstream Products

• 943826-99-1 4-{4-[(4-bromo-2-methylphenyl)(methyl)amino]pyrimidin-4-ylamino}benzonitrile 
• 573982-61-3 N-Methyl-N-(4-methoxybenzyl)-4-bromo-2-methylaniline 
• 573715-27-2 2,2,2-trifluoro-1-(3-methyl-4-methylaminophenyl)-1-(3-trifluoromethyl-phenyl)-ethanol 
• 84712-08-3 5-bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazole-2-one 
• 1392846-26-2 N,2-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 

Relevant academic research and scientific papers

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

N -Methylation of ortho -substituted aromatic amines with methanol catalyzed by 2-arylbenzo [d] oxazole NHC-Ir(iii) complexes

Seven new chelated cyclometalated Ir complexes of ABON,P, ABON,O, and ABON,C(carbene) based on a rigid and tunable 2-arylbenzo[d]oxazole backbone have been prepared for the N-methylation of amines. Among these three coordinated modes, ABON,C(carbene)-chelated iridium-based catalysts exhibited good performance in the monomethylation of aromatic amines with methanol (MeOH) as the green methylation reagent. The steric-modified synthesis of ABON,C(carbene) complexes was described. The most active ABON,C(carbene) complex with marginal steric hindrance as a catalyst was obtained from the benzoxazole ring without a substituent and methyl group of the benzimidazole ring on the N-heterocyclic carbene (NHC) ligand. A variety of amines including para- and meta-substituted aromatic amines, as well as heterocyclic amines, were formulated as suitable substrates. Importantly, this catalyst considerably promoted the yield of the N-methylation of ortho-substituted aromatic amines. Controlled kinetic experiments and deuterium-labeling reactions of these ortho-substituted amines were conducted under optimized conditions. On the basis of the experimental results, a plausible mechanism was proposed.

AMIDO COMPOUNDS AS AhR MODULATORS

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strains

Novel diarylpyrimidines (DAPY), which represent next generation of non-nucleoside reverse transcriptase inhibitors (NNRTIs), were synthesized and their activities against human immunodeficiency virus type I (HIV-1) assessed. Modulations at positions 2 and

Arylsulfonamidobenzylic compounds

Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.

Para-bromination of ortho-alkyl anilines

A process of selectively preparing p-bromo-o-alkylanilines (e.g. 4-bromo-2-methylaniline) by reacting o-alkylanilines (e.g., 2-methylaniline) with unadsorbed bromine in a solvent selected from the group consisting of an inert di- tri- or tetrahaloaliphatic hydrocarbon (e.g., dichloromethane and dibromomethane), an alkyl nitrile (e.g., acetonitrile) and mixtures thereof.