59565-54-7

Basic information

• Product Name: 1,3,4-Thiadiazol-2-amine, 5-(2-methylphenyl)-
• Synonyms: 1,3,4-Thiadiazol-2-amine, 5-(2-methylphenyl)-; 5-(2-Methylphenyl)-1,3,4-thiadiazol-2-amine
• CAS NO: 59565-54-7
• Molecular Formula: C₉H₉N₃S
• Molecular Weight: 191.2529
• Mol File: 59565-54-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 372.5°C at 760 mmHg
• Flash Point: 179.1°C
• Appearance: /
• Density: 1.281g/cm³
• Vapor Pressure: 9.56E-06mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1,3,4-Thiadiazol-2-amine, 5-(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Thiadiazol-2-amine, 5-(2-methylphenyl)-(59565-54-7)
• EPA Substance Registry System: 1,3,4-Thiadiazol-2-amine, 5-(2-methylphenyl)-(59565-54-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 59565-54-7(Hazardous Substances Data)

Usage

General Description

"1,3,4-Thiadiazol-2-amine, 5-(2-methylphenyl)-" is a specific chemical compound that falls under the broader category of organic substances. 1,3,4-Thiadiazol-2-amine, 5-(2-methylphenyl)- includes elements such as nitrogen, sulfur, and carbon, which are common in many organic compounds. A distinct characteristic of the compound is its specific structural arrangement, which includes a thiadiazole ring, an aromatic ring, and a nitrogen atom in its configuration. This chemical is often synthesized in laboratories for research and experimental purposes. The potential use, properties, hazards, and safety measures of this chemical are typically studied by chemists in order to fully comprehend its characteristics and applications.

InChI:InChI=1/C9H9N3S/c1-6-4-2-3-5-7(6)8-11-12-9(10)13-8/h2-5H,1H3,(H2,10,12)

Upstream product

• 2290-65-5 trimethylsilyl isothiocyanate 
• 7658-80-2 2-methylbenzohydrazide 
• 118-90-1 ortho-methylbenzoic acid 
• 79-19-6 thiosemicarbazide 
• 5706-81-0 2'-methylbenzaldehyde-thiosemicarbazone 
• 529-20-4 2-methylphenyl aldehyde 

Downstream Products

• 59565-63-8 furfurylidene-(5-o-tolyl-[1,3,4]thiadiazol-2-yl)-amine 
• 73653-80-2 6-phenyl-2-o-tolyl-imidazo[2,1-b][1,3,4]thiadiazole 
• 1117877-47-0 C₁₉H₁₈ClN₃O₃S₂ 
• 1186388-59-9 C₁₈H₁₅N₃O₃S 
• 1248828-20-7 2-[{5-(2-methylphenyl)-[1,3,4]-thiadiazol-2-yl}imino]-1,3-thiazolidin-4-one 
• 1248828-26-3 5-benzylidene-2-[{5-(2-methylphenyl)-[1,3,4]-thiadiazol-2-yl}imino]-1,3-thiazolidin-4-one 
• 1248828-35-4 2-[{5-(2-methylphenyl)-[1,3,4]-thiadiazol-2-yl}imino]-5-(3,4-dimethoxybenzylidene)-1,3-thiazolidin-4-one 
• 1430197-25-3 4-methyl-N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide 
• 1385074-38-3 2-(valyl-valyl)-amino-5-(2-methylphenyl)-1,3,4-thiadiazole 

Relevant articles and documents

N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound

The invention belongs to the technical field of medicines, relates to a compound with antitumor activity and a specific chemical structure, and in particular relates to an N-((6, 7-dimethoxyquinoline-4-yl) oxy) methyl)-N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound and a preparation method and an application thereof. The structural general formula of the compound is shown in the specification, wherein an R group is mono-substituted or double-substituted phenyl, fluorophenyl, chlorphenyl, bromophenyl, benzyl, benzyloxy, benzene nitro or trifluoromethyl substituted at 2-position, 3-position or 4-position. Pharmacological studies show that the compound provided by the invention has a relatively remarkable proliferation inhibition effect on HER-2 positive breast cancer cells SK-Br-3, the effect is obviously superior to that of HER-2 negative breast cancer cells MCF-7, the compound can be used for preparing antitumor drugs, and a new way is opened up for deep research and development of tumor drugs in the future. The preparation method provided by the invention is simple and feasible, relatively high in yield and easy for large-scale production.

Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies

A series of 15 novel 1,3,4-thiadiazole amide derivatives containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino (4) and amino (5) analogues of a phenyl-substituted 1,3,4-thiadiazole am

Synthesis and anti-inflammatory activity of some new thiadiazole linked pyrazole benzene sulphonamides as cyclooxygenase inhibitors

A new series of thiadiazole linked pyrazole benzenesulfonamide derivatives were synthesized by the condensation of aldehydic pyrazole with aryl substituted thiadiazole amine followed by Schiff base reaction. The synthesized compounds (6a-o) were characterized by IR, NMR, and Mass spectral data, further evaluated their in-vivo anti-inflammatory, analgesic and invitro COX-II inhibition assay. The compounds 6b and 6m showed most significant in-vivo antiinflammatory with 72.33 &71.17% inhibition along analgesic activity having 67.89% and 71.37 % respectively. Their selectivity against COX-II enzyme with selectivity index 67.81 and 66.38 was established for 6b and 6m, which is compared with Celecoxib. During the gastric ulceration study, selected compounds couldn't observed any ulcerogenic effect on gastric mucosa. The in-silico pharmacokinetic profile and molecular docking study exposed very good binding affinity towards the Cyclooxygenase (COX-II) enzyme (PDB Id: 3PGH), therefore the compounds 6b and 6m are used as promising lead candidates for the support of drug development.