59565-54-7

Usage

Uses

Since the provided materials do not specify the applications of 1,3,4-Thiadiazol-2-amine, 5-(2-methylphenyl)-, it is not possible to list its uses based on the given information. However, in general, organic compounds with thiadiazole rings are known for their diverse applications in various fields such as pharmaceuticals, agrochemicals, and materials science. They can be used as:
Active pharmaceutical ingredients (APIs) for the development of new drugs due to their potential biological activities.
Pesticides or agrochemicals for crop protection, leveraging their chemical properties to control pests and diseases.
Building blocks or intermediates in the synthesis of other complex organic molecules with specific functions or properties.
To provide accurate applications for 1,3,4-Thiadiazol-2-amine, 5-(2-methylphenyl)-, further research and information on its specific properties and potential uses would be required.

InChI:InChI=1/C9H9N3S/c1-6-4-2-3-5-7(6)8-11-12-9(10)13-8/h2-5H,1H3,(H2,10,12)

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 79-19-6 thiosemicarbazide 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 7658-80-2 2-methylbenzohydrazide 
• 529-20-4 2-methylphenyl aldehyde 
• 5706-81-0 2'-methylbenzaldehyde-thiosemicarbazone 

Downstream Products

• 59565-63-8 furfurylidene-(5-o-tolyl-[1,3,4]thiadiazol-2-yl)-amine 
• 79225-77-7 N-benzoyl-N'-(5-o-tolyl-1,3,4-thiadiazol-2-yl)thiourea 
• 120450-42-2 2-benzamido-5-o-tolyl-1,3,4-thiadiazole 
• 79225-93-7 5-Phenyl-2-o-tolyl-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-7-thione 
• 79226-04-3 5-(4-Chloro-phenoxymethyl)-2-o-tolyl-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-7-thione 
• 73653-80-2 6-phenyl-2-o-tolyl-imidazo[2,1-b][1,3,4]thiadiazole 
• 1023696-91-4 N-(5-o-tolyl-1,3,4-thiadiazole-2-yl)-N'-(5-methylisoxazoyl)thiourea 
• 1117877-47-0 C₁₉H₁₈ClN₃O₃S₂ 
• 1186388-59-9 C₁₈H₁₅N₃O₃S 
• 148989-33-7 2-chloro-N-[5-(2-methylphenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide 
• 1248828-20-7 2-[{5-(2-methylphenyl)-[1,3,4]-thiadiazol-2-yl}imino]-1,3-thiazolidin-4-one 
• 1248828-26-3 5-benzylidene-2-[{5-(2-methylphenyl)-[1,3,4]-thiadiazol-2-yl}imino]-1,3-thiazolidin-4-one 
• 1248828-35-4 2-[{5-(2-methylphenyl)-[1,3,4]-thiadiazol-2-yl}imino]-5-(3,4-dimethoxybenzylidene)-1,3-thiazolidin-4-one 
• 1385074-38-3 2-(valyl-valyl)-amino-5-(2-methylphenyl)-1,3,4-thiadiazole 

Relevant academic research and scientific papers

N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound

The invention belongs to the technical field of medicines, relates to a compound with antitumor activity and a specific chemical structure, and in particular relates to an N-((6, 7-dimethoxyquinoline-4-yl) oxy) methyl)-N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound and a preparation method and an application thereof. The structural general formula of the compound is shown in the specification, wherein an R group is mono-substituted or double-substituted phenyl, fluorophenyl, chlorphenyl, bromophenyl, benzyl, benzyloxy, benzene nitro or trifluoromethyl substituted at 2-position, 3-position or 4-position. Pharmacological studies show that the compound provided by the invention has a relatively remarkable proliferation inhibition effect on HER-2 positive breast cancer cells SK-Br-3, the effect is obviously superior to that of HER-2 negative breast cancer cells MCF-7, the compound can be used for preparing antitumor drugs, and a new way is opened up for deep research and development of tumor drugs in the future. The preparation method provided by the invention is simple and feasible, relatively high in yield and easy for large-scale production.

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies

A series of 15 novel 1,3,4-thiadiazole amide derivatives containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino (4) and amino (5) analogues of a phenyl-substituted 1,3,4-thiadiazole am

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

Synthesis and anti-inflammatory activity of some new thiadiazole linked pyrazole benzene sulphonamides as cyclooxygenase inhibitors

A new series of thiadiazole linked pyrazole benzenesulfonamide derivatives were synthesized by the condensation of aldehydic pyrazole with aryl substituted thiadiazole amine followed by Schiff base reaction. The synthesized compounds (6a-o) were characterized by IR, NMR, and Mass spectral data, further evaluated their in-vivo anti-inflammatory, analgesic and invitro COX-II inhibition assay. The compounds 6b and 6m showed most significant in-vivo antiinflammatory with 72.33 &71.17% inhibition along analgesic activity having 67.89% and 71.37 % respectively. Their selectivity against COX-II enzyme with selectivity index 67.81 and 66.38 was established for 6b and 6m, which is compared with Celecoxib. During the gastric ulceration study, selected compounds couldn't observed any ulcerogenic effect on gastric mucosa. The in-silico pharmacokinetic profile and molecular docking study exposed very good binding affinity towards the Cyclooxygenase (COX-II) enzyme (PDB Id: 3PGH), therefore the compounds 6b and 6m are used as promising lead candidates for the support of drug development.

One-pot synthesis of 5H-1,3,4-thiadiazolo[3,2-a] pyrimidin-5-one derivatives

A novel and efficient one-pot method has been developed for the synthesis of 2-substituted-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5- one derivative by the combination of [3 + 3] cycloaddition, reduction, deamination reactions. The fused heterocyclic compoun

Synthesis, crystal structure and biological activity of N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

A new 1, 3, 4-thiadiazole compound, N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl) cyclopropanecarboxamide, was synthesized and its structure was confirmed by 1H NMR, MS and HRMS. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test showed that the synthesized compound has moderate herbicidal activity against Brassica campestris and fungicidal activities against Sclerotinia sclerotiorum(Lib.) de Bary, Rhizoctonia solanii, Fusarium oxysporum, Corynespora cassiicola, and Botrytis cinerea.

Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)

A novel and efficient one-pot method has been developed for the synthesis of 2-amino-1,3,4-thiadiazoles using various carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS). In situ preparation of various thiosemicarbazides by the reaction

Synthesis of 2-amino-5-aryl-1,3,4-thiadiazolopeptides as potent antitubercular agents

A novel series of 2-amino-5-aryl-thiadiazole analogs of amino acids and dipeptides were synthesized using 1-ethyl-3-(3- dimethylaminopropyl)carbodiimide as coupling agent and N-methyl morpholine (NMM) as base. Structure of all the newly synthesized compounds was confirmed by IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds were screened for their antitubercular, antibacterial and antifungal activity.

Thiadiazole derivatives as potential anticonvulsant agents

A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids which were cyclized to give differently substituted thiazolidin-4-one. Elemental analysis, IR,1HNMR,13C NMR and mass spectral data confir