59566-50-6

Basic information

• Product Name: 2-(B-MORPHOLINOETHYL)PYRIDINE
• Synonyms: 4-[2-(2-PYRIDYL)ETHYL]MORPHOLINE;2-(BETA-MORPHOLINOETHYL)PYRIDINE;2-(B-MORPHOLINOETHYL)PYRIDINE;4-[2-(2-Pyridinyl)ethyl]morpholine;2-(2-Morpholinoethyl)pyridine;4-(2-pyridin-2-ylethyl)morpholine
• CAS NO: 59566-50-6
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• EINECS: 261-807-3
• Mol File: 59566-50-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 106 °C
• Flash Point: 128.9°C
• Appearance: /
• Density: 1.067g/cm³
• Vapor Pressure: 0.00218mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 2-(B-MORPHOLINOETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(B-MORPHOLINOETHYL)PYRIDINE(59566-50-6)
• EPA Substance Registry System: 2-(B-MORPHOLINOETHYL)PYRIDINE(59566-50-6)

Safety Data

• Hazardous Substances Data: 59566-50-6(Hazardous Substances Data)

Usage

General Description

2-(B-Morpholinoethyl)pyridine is a chemical compound that belongs to the class of pyridine derivatives. It is a heterocyclic organic compound with a morpholine group attached to the pyridine ring. 2-(B-MORPHOLINOETHYL)PYRIDINE has a variety of uses in chemical synthesis and pharmaceutical research. It can be utilized as a building block for the synthesis of various organic compounds and can also be employed as a reagent for the preparation of biologically active molecules. Its unique structure and properties make it an important intermediate for the development of new drugs and pharmaceuticals. Additionally, it can also serve as a ligand in coordination chemistry, enabling the formation of complexes with transition metals for catalytic applications.

InChI:InChI=1/C11H16N2O/c1-2-5-12-11(3-1)4-6-13-7-9-14-10-8-13/h1-3,5H,4,6-10H2

Upstream product

• 100-69-6 2-vinylpyridine 
• 110-91-8 morpholine 
• 103-74-2 2-(2-Hydroxyethyl)pyridine 
• 10024-89-2 morpholin hydrochloride 
• 4542-47-6 3-Morpholin-4-yl-propionitrile 
• 74-86-2 acetylene 

Downstream Products

• 216985-68-1 4-(2-piperidin-2-yl-ethyl)-morpholine 

Relevant articles and documents

Exploring the acidic catalytic role of differently structured deep eutectic solvents in the aza-Michael addition of amines to 2-vinylpiridine

Abstract: The search for innovative and green reaction media is a prominent topic in the recent research in chemistry. Deep Eutectic Solvents (DESs) are currently gaining relevance in this field thanks to their unique properties in terms of their “greenness” as well as in terms of their catalytic properties. In this work we developed an efficient protocol for the conjugate aza-Michael addition of amines to 2-vinylpyridine using 14 differently structured acid DESs as both reaction media and catalysts, so preventing the use of other acid additives. The results are influenced by the acidity of the components of the DESs, showing the best results with weak acids in the DESs components, with isolated yields up to 86%. The aza-Michael reaction is a widely used synthetic route for the C–N bond formation in organic synthesis. In particular, the addition of amines to 2-vinylpyridine is used for the realization of pharmaceutically relevant compounds with anticancer, antiarrhythmic, and analgesic properties. Comparing the results with the ones observed in literature for the same reaction, this procedure revealed to be a convenient and efficient method for this relevant transformation. Graphic abstract: [Figure not available: see fulltext.]

Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition

A clean, mild and sustainable method for the functionalization of pyridines and their analogues is reported. A zinc-based Lewis acid is used to activate pyridine and its analogues towards nucleophilic aromatic substitution, conjugate addition, and cyclization reactions by binding to the nitrogen on the pyridine ring and activating the pyridine ring core towards further functionalization.

One-Flask Pyridylethylation of Amines by 2-(2-Pyridyl)-ethanol

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