59576-28-2

Usage

Uses

Used in Pharmaceutical Research and Development:
Ethanone, 1-(4-methoxy-2-pyridinyl)(9CI) is used as an acetylcholinesterase inhibitor for its potential role in the development of treatments for neurological disorders such as Alzheimer's disease. Its ability to inhibit the enzyme responsible for breaking down acetylcholine in the brain may help improve cognitive function and delay the progression of neurodegenerative diseases.
Used in Organic Synthesis:
Ethanone, 1-(4-methoxy-2-pyridinyl)(9CI) serves as an intermediate in the synthesis of various organic compounds. Its unique chemical structure and properties make it a valuable component in the creation of new drugs and compounds with therapeutic potential, further expanding the scope of pharmaceutical research and development.

Upstream product

• 75-16-1 methylmagnesium bromide 
• 36057-44-0 2-cyano-4-methoxylpyridine 
• 1122-96-9 4-methoxypyridine N-oxide 

Relevant academic research and scientific papers

NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)

PYRAZOLE DERIVATIVE

Not available

Indole compounds as COX-2 inhibitors

This invention provides a compound of the following formula: and the pharmaceutically acceptable salts thereof, wherein L is oxygen or sulfur; Y is a direct bond or C1-4alkylidene; Q is C1-6alkyl, C3-7cycloalkyl, phenyl, naphthyl, heteroaryl or the like; R1is hydrogen, C1-6alkyl or the like; R2is hydrogen, C1-4alkyl, C(O)R5wherein R5is C1-22alkyl or C2-22alkenyl, halosubstituted C1-8alkyl, halosubstituted C2-8alkenyl, —Y—C3-7cycloalkyl, —Y—C3-7cycloalkenyl, phenyl, naphthyl, heteroaryl or the like; X is halo, C1-4alkyl, hydroxy, C1-4alkoxy or the like; and n is 0, 1, 2 or 3, with the proviso that a group of formula —Y—Q is not methyl or ethyl when X is hydrogen; L is oxygen; R1is hydrogen; and R2is acetyl. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.

Substituted indole compounds as anti-inflammatory and analgesic agents

This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein R1is H or C1-4alkyl; R2is C(═L′)R3or So2R4; Y is a direct bond or C1-4alkylene; L and L′ are independently oxygen or sulfur; Q is selected from the following: C1-6alkyl, halo-substituted C1-4alkyl, optionally substituted C3-7cycloalkyl, optionally substituted phenyl or naphthyl, optionally substituted5or6-membered monocyclic aromatic group; R3is —OR6, —NR7R8, N(OR1)R7or a group of formula: Z is a direct bond, O, S or NR5; R4is C1-6alkyl, halo-substituted C1-4alkyl, optionally substituted phenyl or naphthyl; R5is C1-4alkyl or halo-substituted C1-4alkyl; R6is C1-4alkyl C3-7cycloalkyl, C1-4alkyl-C3-7cycloalkyl, halo-substituted C1-4alkyl, optionally substituted C1-4alkyl-phenyl or phenyl; R7and R8are each selected from the following: H, optionally substituted C1-6alkyl, optionally substituted C3-7cycloalkyl, optionally substituted C1-4alkyl-C3-7cycloalkyl, and optionally substituted C1-4alkyl-phenyl or phenyl; X is each selected from halo, C1-4alkyl, halo-substituted C1-4alkyl, OH, C1-4alkoxy, halo-substituted C1-4alkoxy, C1-4alkylthio, NO2, NH2, di-(C1-4alkyl)amino and CN; n is 0, 1, 2 or 3; and r is 1, 2 or 3. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.