5958-05-4Relevant academic research and scientific papers
Preparation process of oxazepam impurity II
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Paragraph 0029-0059, (2020/10/30)
The invention provides a preparation process of an oxazepam impurity II, which comprises the following steps: by using oxazepam as a raw material, adding a catalyst pyruvic acid into a dipole solvent,carrying out heat preservation reaction, and carrying o
Facile thermal rearrangement of Lorazepam and Oxazepam
Siddegowda, Maravanahalli S.,Yathirajan, Hemmige S.,Ramakrishn, Ramesha A.
, p. 1628 - 1632 (2013/01/15)
Lorazepam 1, a very well known anti-convulsant undergo facile thermal rearrangement at about 110°C to 6-chloro-4-(ochlorophenyl)-2- Quinazolinecarboxaldehyde 10 in almost quantitative yield. Oxazepam 2 which is structurally similar, require higher tempera
Characterization of lorazepam and oxazepam by the thermal behavior of their degradation product
Chauvet
, p. 256 - 260 (2007/10/02)
Lorazepam and oxazepam are benzodiazepine which differ by the presence, or not, of chlorine atom on the phenyl ring. These molecules are able of chemical and thermal degradation with water intramolecular elimination between hydroxy and amine functional gr
Characterization of the Fluorescence Derivatization Products of Oxazepam in Mixtures of Acetic Acid and Methanol
Escobal, Ana R.,Iriondo, Carmen,Berrueta, Luis A.,Gallo, Blanca,Vicente, Francisca
, p. 1937 - 1947 (2007/10/02)
The fluorescence of oxazepam in mixtures of acetic acid and methanol was studied.The two reaction products were isolated by semi-preparative High Performance Liquid Chromatography, characterized by pmr, cmr, ir, and ms and identified as 6-chloro-4-phenylq
Quantitative -Elimination of Water from Oxazepam
Kaupp, Gerd,Knichala, Bernd
, p. 462 - 467 (2007/10/02)
Upon heating to 150 deg C, the 1,4-benzodiazepine derivative 1 (oxazepam) eliminates water to form the quinazolinecarbaldehyde 2 quantitatively.This reaction is termed a -elimination and is discussed mechanistically.Deuterium labelling experiment
