59583-11-8Relevant academic research and scientific papers
Pd-catalyzed regioselective arylation on the C-5 position of N-aryl 1,2,3-triazoles
Yamajala, K. Durga Bhaskar,Patil, Mahendra,Banerjee, Shaibal
supporting information, p. 3003 - 3011 (2015/03/30)
We herein report a highly efficient method for the arylation at the C-5 position of N-aryl 1,2,3-triazoles via a direct palladium catalyzed arylation reaction. The optimal reaction conditions required a combination of Pd(OAc)2 and tris(o-tolyl)
Base-mediated reaction of vinyl bromides with aryl azides: One-pot synthesis of 1,5-disubstituted 1,2,3-triazoles
Wu, Luyong,Chen, Yuxue,Luo, Jianheng,Sun, Qi,Peng, Mingsheng,Lin, Qiang
, p. 3847 - 3850 (2014/07/08)
A one-pot base-mediated reaction of azides and β- or α-vinyl bromides has been reported. The effects of bases and solvents have been investigated in the process. A variety of 1,5-disubstituted triazoles were prepared in low to good yields. Further studies reveal that the corresponding alkynes were produced as intermediates via elimination reaction. Under the same reaction conditions, the reactions of alkyl alkynes with phenyl azide would give 1,5-disubstituted 1,2,3-triazoles.
Potassium tert-butoxide promoted cycloaddition reaction for the synthesis of 1,5-disubstituted 1,2,3-triazoles from aromatic azides and trimethylsilyl-protected alkynes
Wu, Luyong,Chen, Yuxue,Tang, Mi,Song, Xinming,Chen, Guangying,Song, Xiaoping,Lin, Qiang
supporting information; experimental part, p. 1529 - 1533 (2012/07/30)
The cycloaddition reaction of aromatic azides and trimethylsilyl alkynes upon treatment with desilylating reagents was investigated. In the process, the use of t-BuOK in wet DMF generated 1,5-disubstituted 1,2,3-triazoles regioselectively in moderate to g
Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited
Krasinski, Antoni,Fokin, Valery V.,Sharpless, K. Barry
, p. 1237 - 1240 (2007/10/03)
After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.
