85862-89-1

Upstream product

• 22001-17-8 3-trifluoromethylphenylazide 
• 1066-26-8 sodium acetylide 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 64214-96-6 5-(4-nitrophenyl)-1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazole 
• 59583-11-8 1-(3-(trifluoromethyl)phenyl)-5-phenyl-1H-1,2,3-triazole 

Relevant academic research and scientific papers

Pd-catalyzed regioselective arylation on the C-5 position of N-aryl 1,2,3-triazoles

We herein report a highly efficient method for the arylation at the C-5 position of N-aryl 1,2,3-triazoles via a direct palladium catalyzed arylation reaction. The optimal reaction conditions required a combination of Pd(OAc)2 and tris(o-tolyl)

Synthesis of trifluoromethyl-substituted N-aryl-poly-1,2,3-triazole derivatives

Synthesis, characterization, and physical properties of -CF3 and -NO2 substituted N-aryl-polytriazole derivatives are reported. The molecules are prepared by a reliable Cu-catalyzed [3 + 2]-cycloaddition between -CF3 substituted aryl azides and alkynes followed by a nitration sequence and also the base-promoted nucleophilic displacement of the halo groups by the 1,2,3-triazoles. The compounds are characterized by analytical and spectroscopic methods; the solid state structures of some of the compounds are confirmed by X-ray diffraction techniques. The synthesized materials decompose in the range of 195-308 °C. Most of the -CF3 and -NO2 groups-bearing aryl triazoles exhibit good densities and acceptable detonation characteristics. Some of the fluorine containing polytriazole-bearing compounds showed positive heats of formation. This journal is the Partner Organisations 2014.

Facile and quick synthesis of 1-monosubstituted aryl 1,2,3-triazoles: A copper-free [3+2] cycloaddition

An efficient copper-free synthesis of 1-monosubstituted aryl 1,2,3-triazoles from sodium acetylide and aryl azides was developed, which was found suitable for various aryl azides and completed within 15 min at room temperature with moderate to excellent y