5959-29-5

Basic information

• Product Name: L-2-Aminobutyric acid hydrochloride
• Synonyms: H-ABU-OH HCL;H-L-2ABU-OH HCL;HOMOALANINE HYDROCHLORIDE;L-2-AMINO-BUTYRIC ACID HYDROCHLORIDE;L-2-AMINOBUTYRIC ACID HYDROCHLORIDE SALT;(S)-2-AMINO-BUTYRIC ACID HYDROCHLORIDE;(S)-2-AMINOBUTANOIC ACID HYDROCHLORIDE;H-2-Abu-OH x HCl
• CAS NO: 5959-29-5
• Molecular Formula: C₄H₉NO₂*ClH
• Molecular Weight: 139.58
• Mol File: 5959-29-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 247.7°C at 760 mmHg
• Flash Point: 103.6°C
• Appearance: /
• Vapor Pressure: 0.00811mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: L-2-Aminobutyric acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-2-Aminobutyric acid hydrochloride(5959-29-5)
• EPA Substance Registry System: L-2-Aminobutyric acid hydrochloride(5959-29-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5959-29-5(Hazardous Substances Data)

Usage

Uses

(S)-2-Aminobutanoic Acid Hydrochloride is an intermediate in the synthesis of Levetiracetam (L331500), which is used as an anticonvulsant.

InChI:InChI=1/C4H9NO2.ClH/c1-2-3(5)4(6)7;/h3H,2,5H2,1H3,(H,6,7);1H

Upstream product

• 40916-98-1 (S)-ethyl 2-aminobutanoate 
• 87068-75-5 S-(+)-2-benzoylamino-n-butyric acid 
• 110449-47-3 <(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl> (2R)-2-aminobutyrate 
• 34047-84-2 (S)-N-benzoyl-3-methylalanine methyl ester 
• 5468-52-0 N-benzoyl-2-aminobutyric acid 
• 2483-62-7 (S)-2-aminobutyric acid methyl ester 

Downstream Products

• 123952-15-8 Boc-Tyr-Abu-OH 
• 7324-11-0 (S)-2-amino-butanamide 
• 677277-70-2 n-propyl (2S)-2-trifluoroacetamidobutyrate 
• 7682-18-0 (S)-2-aminobutyric acid methyl ester hydrochloride 

Relevant articles and documents

Preparation method of chiral alpha-amino acid

The invention discloses a preparation method of chiral alpha-amino acid. Initial raw materials comprising aldehyde and N-acryl substituted glycine undergo Erlenmeyer-Plochl cyclization, hydrolysis or alcoholysis, asymmetric catalytic hydrogenation and acid hydrolysis to obtain the chiral alpha-amino acid compound. The method adopting the above synthesis route has the advantages of mild reaction conditions, simple technological operation, safe and stable production, realization of high yield, good chemical purity and good optical purity of the above obtained product, wide application range, and suitableness for industrial production.

PREPARATION OF (S)-2-AMINOBUTYRIC ACID

Processes for the preparation of (S)-2-aminobutyric acid, embodiments including selective hydrolysis of racemic N-protected-2-aminobutyric acid using an acylase enzyme, such as one derived from Thermococcus litorolis or Aspergillus melleus.

ENANTIOSELECTIVE SYNTHESES OF α-AMINO ACIDS FROM 10-SULFONAMIDO-ISOBORNYL ESTERS AND DI-t-BUTYL AZODICARBOXYLATE

Successive treatment of chiral esters 7 with LDA/Me3SiCl and di-t-butyl azodicarboxylate/TiCl4 and Ti(OiPr)4 gave N,N-di-t-butoxycarbonylhydrazinoesters 11 which on deacylation, hydrogenolysis, transesterification and acidic hydrolysis furnished (2S)-α-amino acid hydrochlorides 13 in good overall yields, high enantiomeric purity and with efficient recovery of the alcohol auxiliary 4.Experimental evidence for the configuration and conformation of the intermediate O-silyl ketene acetals 1 is provided.