5468-52-0

Basic information

• Product Name: 2-(benzoylamino)butanoic acid
• CAS NO: 5468-52-0
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.2258
• Mol File: 5468-52-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 454.9°C at 760 mmHg
• Flash Point: 228.9°C
• Density: 1.188g/cm³
• Vapor Pressure: 4.57E-09mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 2-(benzoylamino)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzoylamino)butanoic acid(5468-52-0)
• EPA Substance Registry System: 2-(benzoylamino)butanoic acid(5468-52-0)

Safety Data

• Hazardous Substances Data: 5468-52-0(Hazardous Substances Data)

Usage

General Description

2-(benzoylamino)butanoic acid, also known as N-benzoylglycine, is a chemical compound with the molecular formula C11H13NO3. It is an amino acid derivative and the N-benzoyl derivative of glycine. 2-(benzoylamino)butanoic acid has been studied for its potential biological and pharmacological properties, including its role as a potential drug target for the treatment of various diseases. It has been investigated for its anti-inflammatory and anticancer properties and has also been studied for its potential as a prodrug in drug delivery systems. 2-(benzoylamino)butanoic acid is a valuable compound in medicinal chemistry research and drug development.

Upstream product

• 201230-82-2 carbon monoxide 
• 55-21-0 benzamide 
• 107-18-6 allyl alcohol 
• 60027-58-9 (Z)-α-N-benzoylamino-2-butenoic acid methylester 
• 79893-94-0 N-benzoyl-α-aminobuttersauremethylester 
• 37791-41-6 4-ethylidene-2-phenyl-5-oxazolone 
• 98-88-4 benzoyl chloride 
• 2835-81-6 2-aminobutanoic acid 
• 4703-38-2 N-benzoylmethionine 
• 4411-93-2 2-ethylidene-4-oxo-4-phenylbutyric acid 
• 7469-23-0 N-benzoyl-DL-allothreonine 
• 7469-23-0 N-benzoyl-DL-threonine 
• 65499-78-7 (Z)-α-N-benzoylamino-2-butenoic acid 
• 51127-16-3 rac-4-ethyl-2-phenyloxazol-5(4H)-one 

Downstream Products

• 57357-34-3 (Di-N-benzoyl-α-aminobutyryloxyjod)-benzol 
• 5959-29-5 S-(+)-2-amino-n-butyric acid hydrochloride 
• 1204591-61-6 C₁₄H₁₇NO₃ 
• 1204591-68-3 C₁₄H₁₇NO₃ 
• 1242985-32-5 (R)-4-ethyl-4-((S)-4-oxohexan-2-yl)-2-phenyloxazol-5(4H)-one 
• 1242985-34-7 (R)-4-ethyl-4-((S)-2-oxoheptan-4-yl)-2-phenyloxazol-5(4H)-one 
• 1242985-30-3 4-((R)-1-((R)-4-ethyl-5-oxo-2-phenyl-4,5-dihydrooxazol-4-yl)-3-oxobutyl)phenyl acetate 
• 1242985-31-4 (R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one 
• 1242985-28-9 (R)-4-((R)-1-(3,4-dimethoxyphenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one 
• 1242985-26-7 (R)-4-ethyl-4-((R)-3-oxo-1-phenylbutyl)-2-phenyloxazol-5(4H)-one 

Relevant articles and documents

Asymmetric Aza-Diels-Alder Reactions of in Situ Generated β,β-Disubstituted α,β-Unsaturated N-H Ketimines Catalyzed by Chiral Phosphoric Acids

A novel asymmetric synthesis of dihydropyridinones with vicinal quaternary stereocenters has been realized by asymmetric aza-Diels-Alder reactions of 3-amido allylic alcohols with oxazolones enabled by chiral phosphoric acid catalysis. A series of aryl/alkyl- and alkyl/alkyl-disubstituted 3-amido allylic tertiary alcohols and 4-substituted oxazolones could be well tolerated in these reactions, producing dihydropyridinones with excellent diastereoselectivities and high enantioselectivities. Mechanistic study and control experiments were performed to shed light on the reaction mechanism, in which a configurationally defined β,β-disubstituted α,β-unsaturated N-H ketimine was proposed as the key intermediate.

Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl α-Amino Acid Derivatives at Room Temperature

An efficient palladium-catalyzed ortho-alkoxylation of N-benzoyl α-amino acid derivatives at room temperature has been explored. This novel transformation, using amino acids as directing groups, Pd(OAc)2 as catalyst, alcohols as the alkoxylation reagents, and PhI(OAc)2 as the oxidant, showed wide generality, good functional tolerance, and high monoselectivity and regioselectivity.

Asymmetric palladium(II)-catalyzed cascade reaction giving quaternary amino succinimides by 1,4-addition and a nef-type reaction

Simple starting materials, high-value products: A dinuclear ferrocene-based PdII complex transforms mixtures of racemic N-benzoyl α-amino acids, nitroolefins, acetic anhydride, and manganese acetate into biologically interesting quaternary amin