5959-35-3

Basic information

• Product Name: 4-aminobutyric acid hydrochloride
• Synonyms: 4-aminobutyric acid hydrochloride;Butanoic acid, 4-aMino-, hydrochloride
• CAS NO: 5959-35-3
• Molecular Formula: C₄H₁₀NO₂*Cl
• Molecular Weight: 139.5807
• EINECS: 227-724-1
• Mol File: 5959-35-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 248°C at 760 mmHg
• Flash Point: 103.8°C
• Appearance: /
• Vapor Pressure: 0.00798mmHg at 25°C
• CAS DataBase Reference: 4-aminobutyric acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aminobutyric acid hydrochloride(5959-35-3)
• EPA Substance Registry System: 4-aminobutyric acid hydrochloride(5959-35-3)

Safety Data

• Hazardous Substances Data: 5959-35-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H9NO2.ClH/c5-3-1-2-4(6)7;/h1-3,5H2,(H,6,7);1H

Upstream product

• 7647-01-0 hydrogenchloride 
• 57294-38-9 N-(tert-butoxycarbonyl)-4-aminobutanoic acid 
• 70288-77-6 4-(Methoxycarbonylamino)buttersaeure-methylester 
• 56-12-2 4-amino-n-butyric acid 
• 81292-85-5 C₈H₁₂N₂O₆P₂^(4-)*4Na⁽¹⁺⁾ 

Downstream Products

• 554412-80-5 5-(benzyloxycarbonyl-methyl-amino)-2-(3-carboxy-propylamino)-4-oxo-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester 
• 137048-10-3 4-amino butyric acid chloride hydrochloride 
• 13031-60-2 methyl γ-aminobutyrate hydrochloride 

Relevant articles and documents

An Efficient Route to N-Monosubstituted Guanidino-Lactams

A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.

Salts of 4-aminobutyric acid and 6-aminohexanoic acid behaving as molecular Velcro

The crystal structures of eight novel carboxyalkylammonium salts, (+H3N(CH2)nCOOH)X-, are reported, with n = 4 and X = Cl, Br and I in structures 1, 2 and 3, respectively, and n = 6 and X = Cl, Br·0.5H2O, Cl·0.5H2O, NO3 and ClO4 in structures 4, 5, 6, 7 and 8. The members of this family of compounds were found to display significant structural diversity, and a careful analysis of the structures employing the principles of crystal engineering was done to explain the observed trends and differences, specifically also the interdigitation or non-interdigitation of alkyl chains. It was found that a primary hydrogen bonding network formed between the ammonium groups and halide or oxo-anions, which plays a major structure-directing role. The structures may be likened to molecular Velcro, in which secondary hydrogen bonding interactions involving the carboxylic acid groups act as "hooks" to link primary networks.

Geminal Diphosphonic Acids Containing Amidino Groups

The reaction of amides or nitriles with H3PO4/PCl3 leads in some cases to the formation of amidinoalkylidenediphophonic acids.In the case of formamide under specified conditions, amidinomethylenediphosphonic acid (4) is formed, with succin- or glutaramides (or with the nitriles) the heterocyclic, geminal diphosphonic acids 10 are obtained.By the reaction of 2-pyrrolidinone 12 with PCl3/H2O in addition to the expected 2,2-pyrrolidinylidenediphosphonic acid (11a) an amidine is isolated, for which the structure 15 is suggested.The alkaline hydrolyses of these compounds and the corresponding reaction products are described.