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Disinomenine is a naturally occurring chemical compound found in the plant Disinorea neorickii, which is native to the tropical regions of Africa. It is a member of the indole alkaloid family and has been studied for its potential antiprotozoal and antimicrobial properties. Disinomenine has shown activity against various parasites, including Trypanosoma brucei, the causative agent of African sleeping sickness, and Plasmodium falciparum, the parasite responsible for malaria. Its mechanism of action is believed to involve the inhibition of certain enzymes and the disruption of cellular processes in the target organisms. While the compound has demonstrated promise in laboratory settings, further research is needed to assess its potential for clinical use and to address any potential side effects or toxicity.

596-58-7

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596-58-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 596-58-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 596-58:
(5*5)+(4*9)+(3*6)+(2*5)+(1*8)=97
97 % 10 = 7
So 596-58-7 is a valid CAS Registry Number.

596-58-7Downstream Products

596-58-7Relevant academic research and scientific papers

Biocatalyzed cross-coupling of sinomenine and 1,2-dihydroxybenzene by Coriolus unicolor

Deng, Zhang Shuang,Zhao, Dan,Hu, Yi,Li, Jian Xin,Zou, Kun,Wang, Jun Zhi

experimental part, p. 321 - 324 (2012/06/01)

Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis (RA). In a continuous research aiming at discovery of sinomenine derivates with better bioactivity, a cross-coupling reaction of sinomenine and 1,2-dihydroxybenzene catalyzed by a fungus Coriolus unicolor afforded an unique CC cross-coupled compound 2, together with (S)-disinomenine and (R)-disinomenine. The structure of 2 was elucidated by MS and NMR spectroscopy. Compound 2 was further assayed for the inhibitory activity on IL-6 overproduction in SW982 cells and exhibited a much more potent activity on IL-6 (96% inhibition) compared with those of (S)-disinomenine and sinomenine (17% and 12% inhibition, respectively).

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