59601-91-1

Basic information

• Product Name: 5,6-dinitro-1H-indazole
• Synonyms: 5,6-dinitro-1H-indazole;Einecs 261-823-0;NSC 49913
• CAS NO: 59601-91-1
• Molecular Formula: C₇H₄N₄O₄
• Molecular Weight: 208.13106
• EINECS: 261-823-0
• Product Categories: Aldehyde Labeling Reagents;Aromatics
• Mol File: 59601-91-1.mol

Chemical Properties

• Melting Point: 234-235°C
• Boiling Point: 506.4°C at 760 mmHg
• Flash Point: 260°C
• Appearance: /
• Density: 1.752g/cm³
• Vapor Pressure: 7.07E-10mmHg at 25°C
• Refractive Index: 1.777
• Storage Temp.: Refrigerator
• CAS DataBase Reference: 5,6-dinitro-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dinitro-1H-indazole(59601-91-1)
• EPA Substance Registry System: 5,6-dinitro-1H-indazole(59601-91-1)

Safety Data

• Hazardous Substances Data: 59601-91-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
5,6-dinitro-1H-indazole is used as a synthetic building block for the creation of various organic compounds. Its unique chemical structure allows it to be a versatile component in the synthesis of a wide range of molecules, contributing to the development of new materials and substances.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5,6-dinitro-1H-indazole is utilized as a key intermediate in the development of novel drugs. Its chemical properties make it suitable for the synthesis of potential therapeutic agents, which can be further modified and optimized for specific medical applications.
Used in Chemical Research:
5,6-dinitro-1H-indazole also plays a significant role in chemical research, where it is employed as a model compound to study various reaction mechanisms and explore new synthetic pathways. This contributes to the advancement of knowledge in organic chemistry and the discovery of innovative chemical processes.
Used in Material Science:
5,6-dinitro-1H-indazole is also used in material science as a component in the development of new materials with specific properties. Its incorporation into different molecular structures can lead to the creation of materials with unique characteristics, such as improved stability, reactivity, or selectivity.

InChI:InChI=1/C7H4N4O4/c12-10(13)6-1-4-3-8-9-5(4)2-7(6)11(14)15/h1-3H,(H,8,9)

Upstream product

• 7597-18-4 6-nitroindazole 

Downstream Products

• 1276662-12-4 2-benzyl-5,6-dinitro-2H-indazole 
• 1276662-11-3 1-benzyl-5,6-dinitro-1H-indazole 
• 1334218-08-4 5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole 
• 1334218-22-2 C₂₂H₂₂N₄O₄ 
• 1334218-24-4 C₂₂H₂₂N₄O₄ 
• 1334218-32-4 8-ethyl-5-nitro-7-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole 
• 1334218-30-2 7-ethyl-5-nitro-8-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole 
• 1334218-39-1 5-nitro-8-phenyl-1,6-dihydropyrrolo[2,3-g]indazole 
• 98549-93-0 5,6-dihydroxy-1H-indazole 
• 7404-68-4 1H-indazole-5,6-diamine 

Relevant articles and documents

BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present invention relates to benzimidazole derivatives and their pharmaceutical compositions and uses, specifically to benzimidazole derivatives of Formula (I), or their stereoisomer, pharmaceutically acceptable salt or solvates thereof, in which R1, R2, R3, R4, R5 and n have the definitions in the description; the present invention further relates to a pharmaceutical composition containing the compounds, methods for preparing the compounds, and use of the compounds for manufacturing of a medicament for prophylaxis and/or treatment of peptic ulcer, ulcer hemorrhage and diseases associated with gastric acid.

Synthesis of 1,6-dihydropyrrolo[2,3-g]indazoles using Larock indole annulation

The synthesis of 1,6-dihydropyrrolo[2,3-g]indazole derivatives is described. The indolic ring system is constructed via a Larock palladium-catalyzed annulation using terminal and internal alkynes. Additionally, when using internal alkynes for this reaction, we found that a directing effect on regioselectivity was mediated by the ester group of alkyl 3-substituted propiolate derivatives.

Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives

The synthesis of new pyrazolo[3,4-g]quinoxaline derivatives, as well as their Pim kinases (Pim-1, Pim-2, Pim-3) inhibitory potencies and in vitro antiproliferative activities toward a human fibroblast primary culture and three human solid cancer cell lines (PA1, PC3 and DU145) are described. The results obtained in this preliminary structure-activity relationship study have pointed out that most of the compounds in this series exhibited interesting in vitro Pim-3 kinase inhibitory potencies. Moreover, some of the tested compounds have demonstrated favorable antiproliferative potencies.