59607-71-5

Usage

InChI:InChI=1/C8H6N2O3S/c1-13-6-2-3-8(14-5-9)7(4-6)10(11)12/h2-4H,1H3

Upstream product

• 540-72-7 sodium thiocyanide 
• 96-96-8 4-methoxy-2-nitroaniline 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 14371-84-7 4,4′-dimethoxy-2,2′-dinitro-diphenyl disulfide 
• 959144-33-3 4-methoxy-2-nitro-1-[(trifluormethyl)thio]benzene 
• 1354030-29-7 5-(3-(4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl)propoxy)benzo[d]thiazole 
• 1354030-27-5 5-(4-(4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl)butoxy)benzo[d]thiazole 
• 1354030-71-9 5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)benzo[d]thiazole 
• 1354030-52-6 5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole 
• 1354030-51-5 UNC₉₉₉₄ 
• 1354030-50-4 5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)benzo[d]thiazole 
• 4274-41-3 2-amino-4-methoxy-benzenethiol; hydrochloride 
• 7686-41-1 5-hydroxybenzothioazole 
• 2942-14-5 5-methoxy-1,3-benzothiazole 

Relevant academic research and scientific papers

Iron-Catalyzed Decarboxylation of Trifluoroacetate and Its Application to the Synthesis of Trifluoromethyl Thioethers

Nucleophilic CF3 has been generated by decarboxylation of potassium trifluoroacetate, arguably the most easy-to-handle, inexpensive, and sustainable source of trifluoromethyl groups. Simple iron(II) chloride catalyzes the decarboxylation as well as a subsequent trifluoromethylation of organothiocyanates, resulting in a straightforward synthesis of trifluoromethyl thioethers. The KCN byproduct is absorbed by iron(II) with formation of nontoxic potassium hexacyanoferrate. An analogous trifluoromethylation of aldehydes with trifluoroacetate underlines the synthetic potential of such iron-catalyzed decarboxylative trifluoromethylations.

FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS

The present invention relates to novel functionally selective ligands of dopamine D2 receptors, including agonists, antagonists, and inverse agonists. The invention further relates to the use of these compounds for treating central nervous system disorders related to D2 receptors.