596093-60-6Relevant academic research and scientific papers
A new enlargement methodology for the preparation of 2H-1- and 2H-3-benzazepin-2-one derivatives
Jean-Gérard, Ludivine,Pauvert, Micka?l,Collet, Sylvain,Guingant, André,Evain, Michel
, p. 11250 - 11259 (2008/03/12)
An investigation of the one-carbon homologation of some 1-tribromomethyl-isoquinoline and 2-tribromomethyl-quinoline derivatives was conducted. Under the influence of an aqueous solution of silver nitrate in the presence of a nucleophilic species (MeOH, H
Silver nitrate-promoted ring enlargement of 1-tribromomethyl-1,2-dihydro- and 1-tribromomethyl-1,2,3,4-tetrahydro-isoquinoline derivatives: Application to the synthesis of the anti-anginal zatebradine
Pauvert, Micka?l,Collet, Sylvain,Guingant, André
, p. 4203 - 4206 (2007/10/03)
The one step AgNO3-mediated ring enlargement of 1-tribromomethyl-1,2-dihydro- and 1-tribromomethyl-1,2,3,4-tetrahydro-isoquinoline derivatives into 1,2-dihydro- and 1,2,3,4-tetrahydro-benzo[d]azepin-2-ones, respectively, is reported. This reaction offers a convenient entry to potentially active substances such as the anti-anginal zatebradine.
