596103-06-9

Basic information

• Product Name: 1,4-Anhydro-2,3-O-isopropylidene-4-thio-D-ribitol
• Synonyms: 1,4-Anhydro-2,3-O-isopropylidene-4-thio-D-ribitol;((3aS,4R,6aR)-2,2-Dimethyltetrahydrothieno[3,4-d][1,3]dioxol-4-yl)methanol;1,4-Anhydro-2,3-di-O-isopropylidene-4-thio-D-ribitol;1,4-Dideoxy-1,4-epithio-2,3-O-(1-methylethylidene)-D-ribitol
• CAS NO: 596103-06-9
• Molecular Formula: C₈H₁₄O₃S
• Molecular Weight: 190.25996
• Mol File: 596103-06-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 56-60 °C
• Boiling Point: 301.2±32.0 °C(Predicted)
• Appearance: /
• Density: 1.178±0.06 g/cm3(Predicted)
• PKA: 14.14±0.10(Predicted)
• CAS DataBase Reference: 1,4-Anhydro-2,3-O-isopropylidene-4-thio-D-ribitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Anhydro-2,3-O-isopropylidene-4-thio-D-ribitol(596103-06-9)
• EPA Substance Registry System: 1,4-Anhydro-2,3-O-isopropylidene-4-thio-D-ribitol(596103-06-9)

Safety Data

• Hazardous Substances Data: 596103-06-9(Hazardous Substances Data)

Usage

Chemical family

Ribitols, which are sugar alcohols.

Presence of functional groups

Thiol group (sulfhydryl group) and isopropylidene group.

Isopropylidene group function

Protective group used in organic synthesis.

Potential applications

Organic chemistry, pharmaceuticals, and biochemistry research.

Use as a building block

Synthesis of more complex molecules.

Use as a reagent

Various chemical reactions.

Unique chemical properties

Imparted by the thiol group, useful in specific chemical processes.

Diverse potential uses

Different fields of science and industry.

Upstream product

• 49561-21-9 (3aR,6S,6aR)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4(3aH)-one 
• 22430-23-5 L-mannono-1,4-lactone 
• 218906-61-7 methyl 5-thio-β-L-arabinopyranoside 
• 152006-17-2 2,3-O-isopropylidene-L-lyxono-1,4-lactone 
• 1320269-77-9 tert-butyl (((3aS_.4R_.6aR)-2,2-dimethyltetrahydrothieno[3,4-d][1,3]dioxol-4-yl)methoxy)diphenylsilane 
• 1320269-76-8 (3aR,6S,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4(3aH)-one 
• 1006032-29-6 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1,4-di-O-methanesulfonyl-L-lyxitol 
• 546-67-8 lead(IV) tetraacetate 
• 96243-58-2 D-gulono-γ-lactone 
• 596103-04-7 (3aS,4R,6aR)-4-((4R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyltetrahydrothieno[3,4-d][1,3]dioxolane 
• 596103-05-8 (1R)-1-((3aS,4R,6aR)-2,2-dimethyl-tetrahydro-thieno[3,4-d][1,3]dioxol-4-yl)-ethane-1,2-diol 
• 67642-42-6 2,3,5,6-di-O-isopropylidene-D-gulono-1,4-lactone 
• 6322-07-2 D-gulono-1,4-lactone 
• 117859-45-7 methanesulfonic acid (S)-((4R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-((4S,5S)-5-methanesulfonyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl ester 

Downstream Products

• 871913-84-7 Benzoic acid (3aS,4R,6R,6aR)-6-(2-chloro-6-cyclopropylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-thieno[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 871913-85-8 Benzoic acid (3aS,4R,6R,6aR)-6-(2-chloro-6-cyclopentylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-thieno[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 871913-86-9 Benzoic acid (3aS,4R,6R,6aR)-6-[2-chloro-6-(2-methyl-benzylamino)-purin-9-yl]-2,2-dimethyl-tetrahydro-thieno[3,4-d][1,3]dioxol-4-ylmethyl ester 

Relevant articles and documents

Synthesis and Properties of 4′-ThioLNA/BNA

To develop a new nucleoside analogue applicable to oligonucleotide therapeutics, we designed a 4′-thio analogue of an LNA/BNA monomer. Synthesis of 4′-hydroxymethyl-4′-thioribonucleoside was achieved by a tandem ring-contraction-aldol reaction of a 5-thio

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

Synthesis of 4′-ethynyl-2′-deoxy-4′-thioribonucleosides and discovery of a highly potent and less toxic NRTI

The synthesis of 4′-ethynyl-2′-deoxy-4′- thioribonucleosides was carried out utilizing an electrophilic glycosidation in which 4-ethynyl-4-thiofuranoid glycal 16 served as a glycosyl donor. Electrophilic glycosidation between 16 and the silylated nucleoba