871913-84-7Relevant academic research and scientific papers
Structure-activity relationships of 2-chloro-N6-substituted-4′-thioadenosine-5′-N,N-dialkyluronamides as human A3 adenosine receptor antagonists
Jeong, Lak Shin,Lee, Hyuk Woo,Kim, Hea Ok,Tosh, Dilip K.,Pal, Shantanu,Choi, Won Jun,Gao, Zhan-Guo,Patel, Amit R.,Williams, Wanda,Jacobson, Kenneth A.,Kim, Hee-Doo
, p. 1612 - 1616 (2008/09/19)
On the basis of potent and selective A3 adenosine receptor (AR) antagonist, 2-chloro-N6-(3-iodobenzyl)-4′-thioadenosine-5′-N,N-dimethyluronamide, structure-activity relationships were studied for a series of 5′-N,N-dialkyluronamide d
Structure-activity relationships of 2-chloro-N6-substituted- 4′-thioadenosine-5′-uronamides as highly potent and selective agonists at the human A3 adenosine receptor
Jeong, Lak Shin,Lee, Hyuk Woo,Jacobson, Kenneth A.,Kim, Hea Ok,Shin, Dae Hong,Lee, Jeong A.,Gao, Zhan-Guo,Lu, Changrui,Duong, Heng T.,Gunaga, Prashantha,Lee, Sang Kook,Jin, Dong Zhe,Chun, Moon Woo,Moon, Hyung Ryong
, p. 273 - 281 (2007/10/03)
We have established structure-activity relationships of novel 4′-thionucleoside analogues as the A3 adenosine receptor (AR) agonists. Binding affinity, selectivity toward other AR subtypes, and efficacy in inhibition of adenylate cyclase were studied. Fro
