596104-94-8Relevant academic research and scientific papers
Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ12, 14-PGJ2
Kim, Kyeojin,Park, Jong-Min,Kim, Nam-Jung,Kim, Su-Jung,Moon, Hyunyoung,An, Hongchan,Lee, Jeeyeon,Park, Hyun-Ju,Surh, Young-Joon,Suh, Young-Ger
, p. 1900 - 1904 (2016)
Mechanism-based chemical transformation of 15-deoxy-Δ12, 14-PGJ2 (15d-PGJ2) resulted in a series of new NF-E2-related factor-2 (Nrf2) activators and detailed elucidation of the function of each electrophilic binding site. In addition, HO-1 expression resulting from Nrf2 activation through enhanced dissociation of the Keap1–Nrf2 complex by the new activators was proved.
Total Synthesis of Prostaglandin 15d-PGJ2 and Investigation of its Effect on the Secretion of IL-6 and IL-12
Egger, Julian,Fischer, Stefan,Bretscher, Peter,Freigang, Stefan,Kopf, Manfred,Carreira, Erick M.
supporting information, p. 4340 - 4343 (2015/09/15)
An efficient synthesis of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2, 1) is reported. The route described allows for diversification of the parent structure to prepare seven analogues of 1 in which the positioning of electrophilic sites is varied. These analogues were tested in SAR studies for their ability to reduce the secretion of proinflammatory cytokines. It was shown that the endocyclic enone is crucial for the bioactivity investigated and that the conjugated ω-side chain serves in a reinforcing manner.
