869801-12-7

Basic information

• Product Name: (S,E)-4-((Z)-7-((4-methoxybenzyl)oxy)hept-2-en-1-yl)-5-((E)-oct-2-en-1-ylidene)cyclopent-2-enone
• Synonyms: (S,E)-4-((Z)-7-((4-methoxybenzyl)oxy)hept-2-en-1-yl)-5-((E)-oct-2-en-1-ylidene)cyclopent-2-enone
• CAS NO: 869801-12-7
• Molecular Weight: 422.608
• Mol File: 869801-12-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S,E)-4-((Z)-7-((4-methoxybenzyl)oxy)hept-2-en-1-yl)-5-((E)-oct-2-en-1-ylidene)cyclopent-2-enone(CAS DataBase Reference)
• NIST Chemistry Reference: (S,E)-4-((Z)-7-((4-methoxybenzyl)oxy)hept-2-en-1-yl)-5-((E)-oct-2-en-1-ylidene)cyclopent-2-enone(869801-12-7)
• EPA Substance Registry System: (S,E)-4-((Z)-7-((4-methoxybenzyl)oxy)hept-2-en-1-yl)-5-((E)-oct-2-en-1-ylidene)cyclopent-2-enone(869801-12-7)

Safety Data

• Hazardous Substances Data: 869801-12-7(Hazardous Substances Data)

Upstream product

• 131375-69-4 5-((4-methoxybenzyl)oxy)pentanal 
• 2548-87-0 (E)-2-Octenal 
• 676236-01-4 (4R)-4-{(2Z)-7-[(4-methoxybenzyl)oxy]hept-2-en-1-yl}cyclopent-2-en-1-one 
• 824-94-2 p-methoxybenzyl chloride 
• 111-29-5 1 ,5-pentanediol 
• 676236-00-3 (1S,4R,2'Z)-1-[(tert-butyldimethylsilyl)oxy]-4-[7'-(4-methoxybenzyloxy)-2'-heptenyl]-2-cyclopentene 
• 869801-10-5 (1S,4R,2'Z)-4-[7'-(4-methoxybenzyloxy)-2'-heptenyl]-2-cyclopenten-1-ol 
• 676235-98-6 [(1S,4S)-4-[(tert-butyldimethylsilyl)oxy]-2-cyclopenten-1-yl]ethanal 
• 115074-49-2 (1R,4S)-4-[(tert-butyldimethylsilyl)oxy]-2-cyclopentene-1-yl acetate 
• 120052-54-2 (1S,3S)-1-hydroxy-3-(methyl-carboxymethyl)-4-cyclopentene 
• 120052-50-8 2-<(1R,4S)-4-hydroxycyclopent-2-enyl>malonsaeure-dimethylester 
• 426226-00-8 dimethyl 2-((1R,4S)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-en-1-yl)malonate 
• 660430-04-6 methyl 2-((1S,4S)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-en-1-yl)acetate 

Downstream Products

• 87893-55-8 15d-PGJ₂ 
• 596104-94-8 (Z)-7-((R,E)-2-((E)-oct-2-en-1-ylidene)-3-oxocyclopentyl)hept-5-enoic acid 

Relevant articles and documents

Total Synthesis of Prostaglandin 15d-PGJ2 and Investigation of its Effect on the Secretion of IL-6 and IL-12

An efficient synthesis of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2, 1) is reported. The route described allows for diversification of the parent structure to prepare seven analogues of 1 in which the positioning of electrophilic sites is varied. These analogues were tested in SAR studies for their ability to reduce the secretion of proinflammatory cytokines. It was shown that the endocyclic enone is crucial for the bioactivity investigated and that the conjugated ω-side chain serves in a reinforcing manner.

METHOD FOR PRODUCING PROSTAGLANDIN DERIVATIVE, PROSTAGLANDIN DERIVATIVE, INTERMEDIATE COMPOUND THEREFOR AND METHOD FOR PRODUCING THE SAME

PROBLEM TO BE SOLVED: To provide a method for producing a prostaglandin derivative, the prostaglandin derivative and an intermediate compound therefor, especially a method for producing a δ-12-prostaglandin J2 derivative using a new method for chemical synthesis through the intermediate compound. SOLUTION: The method for production is a method for producing the prostaglandin derivative using (1R,3R)-4-cyclopentene-1,3-diol 3-acetate (carboxylate) as a starting material. The method is composed of (A) an α-side chain introduction step of providing a malonic acid ester addition compound at the 3-position of the (1R,3R)-4-cyclopentene-1,3-diol, (B) an α-side chain extension step of affording a (1R,3R)-4-cyclopenten-1-one compound having the α-side chain of the prostaglandin derivative at the 3-position and (C) a prostaglandin derivative synthesizing step of conversion into the prostaglandin derivative.