59611-57-3

Basic information

• Product Name: N-(4-chloro-2-methylquinolin-6-yl)acetamide
• CAS NO: 59611-57-3
• Molecular Formula: C₁₂H₁₁ClN₂O
• Molecular Weight: 234.6815
• Mol File: 59611-57-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 442.1°C at 760 mmHg
• Flash Point: 221.2°C
• Density: 1.317g/cm³
• Vapor Pressure: 5.17E-08mmHg at 25°C
• Refractive Index: 1.665
• CAS DataBase Reference: N-(4-chloro-2-methylquinolin-6-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chloro-2-methylquinolin-6-yl)acetamide(59611-57-3)
• EPA Substance Registry System: N-(4-chloro-2-methylquinolin-6-yl)acetamide(59611-57-3)

Safety Data

• Hazardous Substances Data: 59611-57-3(Hazardous Substances Data)

Upstream product

• 63304-45-0 (E)-ethyl 3-((4-acetamidophenyl)amino)but-2-enoate 
• 500349-77-9 1-(4-hydroxy-2-methyl-[6]quinolyl)-ethanone 
• 500349-72-4 1-(4-chloro-2-methyl-[6]quinolyl)-ethanone 
• 1131-34-6 6-amino-2-methylquinolin-4-ol 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 1140-81-4 N-(4-hydroxy-2-methylquinolin-6-yl)acetamide 

Downstream Products

• 60504-61-2 N,N'-bis-(6-amino-2-methyl-[4]quinolyl)-hexanediyldiamine 
• 100795-23-1 N-(4-methoxy-2-methyl-6-quinolyl)acetamide 

Relevant articles and documents

Amide derivatives and nociceptin antagonists

The present invention relates to a compound of the formula [1′] wherein R2is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.