596111-53-4

Upstream product

• 64-18-6 formic acid 
• 596111-58-9 2R-[(benzyloxyamino)methyl]-6-heptenoic acid 
• 1119-60-4 hept-6-enoic acid 
• 21430-12-6 6-heptenoyl chloride 
• 204711-93-3 4S-benzyl-3-(6-heptenoyl)-oxazolidin-2-one 
• 666831-75-0 2R-hydroxymethyl-6-heptenoic acid 
• 596111-57-8 N-benzyloxy-α-(4-penten-1-yl)-β-lactam 
• 596111-56-7 N-benzyloxy-2R-hydroxymethyl-6-heptenamide 
• 596111-55-6 4S-benzyl-3-(2R-hydroxymethyl-6-heptenoyl)-oxazolidin-2-one 

Downstream Products

• 596111-59-0 N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclopentadec-10-en-6-ylmethyl)-N-benzyloxyformamide 
• 774226-91-4 N^α-{[(2R-N-benzyloxy-N-formylamino)methyl]-6-heptenoyl}-N-(10-undecen-1-yl)-N^ε-tert-butoxycarbonyl-L-lysinamide 
• 774226-90-3 N^α-{[(2R-N-benzyloxy-N-formylamino)methyl]-6-heptenoyl}-N-(5-hexen-1-yl)-N^ε-tert-butoxycarbonyl-L-lysinamide 
• 774226-76-5 2R-[(N-benzyloxy-N-formylamino)methyl]-N-{1-(10-undecenylcarbamoyl)-2,2-dimethylpropyl}-6-heptenoic acid amide 
• 774226-75-4 2R-[(N-benzyloxy-N-formylamino)methyl]-N-{1-(7-octenylcarbamoyl)-2,2-dimethylpropyl}-6-heptenoic acid amide 
• 774226-74-3 N^α-{[(2R-N-benzyloxy-N-formylamino)methyl]-6-heptenoyl}-N-(6-hepten-1-yl)-L-tert-leucinamide 
• 774226-73-2 2R-[(N-benzyloxy-N-formylamino)methyl]-N-{1-(3-butenylcarbamoyl)-2,2-dimethylpropyl}-6-heptenoic acid amide 
• 596111-52-3 N^α-{[(2R-N-benzyloxy-N-formylamino)methyl]-6-heptenoyl}-N-(5-hexen-1-yl)-L-tert-leucinamide 

Relevant academic research and scientific papers

Structure-based design of a macrocyclic inhibitor for peptide deformylase

A macrocyclic, peptidomimetic inhibitor of peptide deformylase was designed by covalently cross-linking the P1′ and P3′ side chains. The macrocycle, which contains an N-formylhydroxylamine side chain as the metal-chelating group, was synthesized from a diene precursor via olefin metathesis using Grubbs's catalyst. The cyclic inhibitor showed potent inhibitory activity toward Escherichia coli deformylase (Ki = 0.67 nM) and antibacterial activity against both Gram-positive and Gram-negative bacteria (MIC = 0.7-12 μg/mL).