59615-87-1Relevant academic research and scientific papers
Thieno[3,2-d]pyrimidine EGFR/ErbB2 dual-target inhibitor, and preparation method and use thereof
-
, (2017/08/31)
The invention relates to a compound shown by a general formula (1) or a pharmaceutically acceptable salt thereof, wherein R1 is selected from C1-C6 alkyl, aryl, C1-C6 alkylaryl; R2s are the same or different, and are selected from H, halogen, C1-C6 alkyl,
THE USES OF ETHYL CYANOBROMOACETATE IN HETEROCYCLIC SYNTHESIS: NOVEL SYNTHESIS OF THIOPHENE, PYRAZOLO-THIAZOLE AND THIENOPYRIDAZINE DERIVATIVES
Mohareb, Rafat Milad,El-Kousy, Salah,El-Torgoman, Abdel Monem
, p. 1747 - 1757 (2007/10/02)
The reaction of active methylene reagents Ia -Ie with phenyl isothiocyanate in basic N,N-dimethylformamide solution followed by cyclization with ethyl cyanobromoacetate II affords the acyclic thioether derivatives IVa - IVe.The use of IVa - IVe in heteroc
