144558-55-4Relevant academic research and scientific papers
Synthesis of some novel thieno[3,2-d]pyrimidines as potential cytotoxic small molecules against breast cancer
Kandeel, Manal,Abdelhameid, Mohammed Kamal,Eman, Kamal,Labib, Madlen Berty
, p. 637 - 647 (2013)
A variety of novel thieno[3,2-d]pyrimidines with different decorating functional groups were synthesized as a part of a study aiming to enrich the arsenal of chemotherapeutic agents for the treatment of cancer. The design of synthetic molecules based on DNA-interchelating properties by hydrogen bond formation. The reported compounds herein are: 4-aminothienopyrimidine derivatives 4a, b and their 4-substituted phenylamino analogues 8a, b; 4-thienopyrimidin-4-ones 5a, b; N-alkyl thienopyrimidin-4-ones 6a-g; 4-chlorothienopyrimidines 7a, b and thienopyrimidoquinazolinones 9a, b which are the structural mimics of 8a, b. The synthesized molecules were evaluated for their in vitro cytotoxic activity against human breast cancer cell line (MCF-7). Biological screening revealed varying cytotoxic potencies of the tested molecules compared with Doxorubicin as a reference drug. The cytotoxicity results from the study suggested that the synthesized molecules are potential antitumor agents and compound 4a was the most potent with an IC50 2.04 nM.
THE USES OF ETHYL CYANOBROMOACETATE IN HETEROCYCLIC SYNTHESIS: NOVEL SYNTHESIS OF THIOPHENE, PYRAZOLO-THIAZOLE AND THIENOPYRIDAZINE DERIVATIVES
Mohareb, Rafat Milad,El-Kousy, Salah,El-Torgoman, Abdel Monem
, p. 1747 - 1757 (2007/10/02)
The reaction of active methylene reagents Ia -Ie with phenyl isothiocyanate in basic N,N-dimethylformamide solution followed by cyclization with ethyl cyanobromoacetate II affords the acyclic thioether derivatives IVa - IVe.The use of IVa - IVe in heteroc
