59615-88-2

Upstream product

• 144558-68-9 Cyano-(2,2-dicyano-1-phenylamino-vinylsulfanyl)-acetic acid ethyl ester 
• 7157-92-8 4-amino-5-aminocarbonyl-3-phenyl-2,3-dihydro-[1,3]thiazole-2-thione 
• 7202-71-3 ethyl 4-amino-2,3-dihydro-3-phenyl-2-thioxothiazole-5-carboxylate 
• 103-72-0 phenyl isothiocyanate 
• 64773-74-6 α,α-Dicyanthioacetanilid 
• 81402-91-7 4-Amino-2-dicyanomethylene-3-phenyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 81402-87-1 4-Amino-2-dicyanomethylene-3-phenyl-2,3-dihydro-thiazole-5-carboxylic acid amide 

Downstream Products

• 552891-00-6 4-chloro-6-phenylaminothieno[3,2-d][1,2,3]triazin-7-carbonitrile 
• 552890-93-4 4-amino-6-phenylaminothieno[3,2-d]pyrimidin-7-carbonitrile 
• 552890-96-7 N-(2,4-dicyano-5-phenylamino-thiophen-3-yl)-formimidic acid ethyl ester 
• 552890-98-9 8-phenylaminothieno[3,2-d][1,2,4]triazolo[3,2-f]pyrimidin-7-carbonitrile 
• 552890-97-8 3-amino-3,4-dihydro-4-imino-6-phenylaminothieno[3,2-d]pyrimidin-7-carbonitrile 
• 552890-94-5 6-phenylamino-4-benzylidenaminothieno[3,2-d]pyrimidin-7-carbonitrile 
• 552891-01-7 9-amino-4-chloro-7-oxo-6-phenyl-6,7-dihydropyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-8-carbonitrile 
• 552891-03-9 3-amino-2,4-di(4,5-dihydro-1H-2-imidazolyl)-5-phenylaminothiophene 

Relevant academic research and scientific papers

Heterocyclic Synthesis With Isothiocyanates: An Expeditious Synthetic Route to Polyfunctionally Substituted Thiophene, Pyrazole, Oxazole, 2,3-Dihydrothiazole, 2-(Pyrazol-4-ylidene)thiazole and 5-(thiazol-2-ylidene)pyrimidine Derivatives

The acidic methylene reagents 1a-e react with phenyl isothiocyanate followed by reaction with bromomalononitrile to afford acyclic and cyclic products 3,4,8,9 and 14a-c depending on the nature of the active methylene reagent used.The reactivions of the products towards different chemical reagents to afford thiophene, pyrazole, oxazole and pyrimidine derivatives were studied.

THE USES OF ETHYL CYANOBROMOACETATE IN HETEROCYCLIC SYNTHESIS: NOVEL SYNTHESIS OF THIOPHENE, PYRAZOLO-THIAZOLE AND THIENOPYRIDAZINE DERIVATIVES

The reaction of active methylene reagents Ia -Ie with phenyl isothiocyanate in basic N,N-dimethylformamide solution followed by cyclization with ethyl cyanobromoacetate II affords the acyclic thioether derivatives IVa - IVe.The use of IVa - IVe in heteroc

On the Chemistry of 4-Aminothiazoline-2-thiones

4-Aminothiazolin-2-one-hydrazones 3 are obtained by succesive treatment of the title compound 1 with dimethyl sulfate and hydrazinehydrate.The rearrangement of 4-aminothiazolin-2-ylidenmalononitrile 7 derived from 1 yields the 2,4-diamino-thiophene deriva