59618-76-7

Upstream product

• 91-56-5 indole-2,3-dione 
• 100-39-0 benzyl bromide 
• 1217-89-6 1-benzylisatin 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 1210948-91-6 diethyl 1-benzyl-3-(4-chlorophenylamino)-2-oxoindolin-3-ylphosphonate 
• 1482498-45-2 N-(4-chlorophenyl)-N',N',N'’,N’'-tetramethyl-N-(1-benzyl-2-oxo-2,3-dihydro-1H-indol-3-yl)phosphoric triamide 

Relevant academic research and scientific papers

α-Selective Allylation of Isatin Imines Using Metallic Barium

The Barbier-type allylation of isatin imines with allylic chlorides was achieved by using metallic barium as the promoter. Various α-allylated 3-amino-2-oxindoles were synthesized from the corresponding allylic chlorides and isatin imines. The double-bond geometry of allylic chlorides was retained throughout the reaction. An arylic bromide or iodide functionality of the products was robust to metalation under the optimum reaction conditions.