59621-76-0

Usage

Uses

Used in Organic Synthesis:
4-(4-CHLORO-PHENOXY)-BENZENETHIOL is used as a building block in organic synthesis for the creation of a variety of organic compounds. Its unique structure and properties contribute to the synthesis process, making it a valuable component in this field.
Used in Chemical Research:
In chemical research, 4-(4-CHLORO-PHENOXY)-BENZENETHIOL serves as an important compound for studying various chemical reactions and properties. Its presence in experiments can provide insights into the behavior of similar compounds and contribute to the advancement of chemical knowledge.
Used in Pharmaceutical Development:
4-(4-CHLORO-PHENOXY)-BENZENETHIOL is used as a component in the development of pharmaceuticals. Its unique structure and properties make it a promising candidate for the creation of new drugs and therapeutic agents.
Used in Agrochemical Development:
In the agrochemical industry, 4-(4-CHLORO-PHENOXY)-BENZENETHIOL is utilized in the development of new agrochemicals. Its properties can contribute to the creation of more effective and targeted products for agricultural use.
Used in Materials Science:
4-(4-CHLORO-PHENOXY)-BENZENETHIOL is also used in materials science for the development of new materials with specific properties. Its unique structure can be leveraged to create materials with improved characteristics for various applications.

InChI:InChI=1/C12H9ClOS/c13-9-1-3-10(4-2-9)14-11-5-7-12(15)8-6-11/h1-8,15H

Upstream product

• 101-79-1 4-amino-4'-chlorodiphenyl ether 
• 100-00-5 4-chlorobenzonitrile 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 59621-46-4 2-[4-(4-Chloro-phenoxy)-phenylsulfanyl]-2-methyl-propionic acid 
• 59621-42-0 4-(4-Chlorphenoxy)-phenylessigsaeure 
• 51338-03-5 (+/-)-2-[4-(4-chlorophenoxy)-phenylthio]-propionic acid 
• 59621-71-5 2-[4-(4-Chlorophenoxy)phenylthio]-ethanol 
• 1026425-51-3 3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-oxo-propyl}-1,5,5-trimethyl-imidazolidine-2,4-dione 
• 193021-78-2 4-[4-(4-chlorophenoxy)phenylthiomethyl]-tetrahydropyran-4-carboxylic acid 
• 59621-43-1 2-[4-(4-Chloro-phenoxy)-phenylsulfanyl]-N-(2-hydroxy-ethyl)-acetamide 
• 59621-44-2 2-{2-[4-(4-Chloro-phenoxy)-phenylsulfanyl]-ethylamino}-ethanol 
• 59621-77-1 [4-(4-Chlorophenoxy)-phenylthio]-2-chloroethane 

Relevant academic research and scientific papers

Phenoxyphenyl sulfone N-formylhydroxylamines (Retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors

A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matrix metalloproteinases (MMP) inhibitors. The substitution of the ether linkage of ABT-770 (5) with a sulfone group 13a led to a substantial increase in activity against MMP-9 but was accompanied by a loss of selectivity for inhibition of MMP-2 and -9 over MMP-1 and diminished oral exposure. Replacement of the biphenyl P1′ substituent with a phenoxyphenyl group provided compounds that are highly selective for inhibition of MMP-2 and -9 over MMP-1. Optimization of the substituent adjacent to the retrohydroxamate center in this series led to the clinical candidate ABT-518 (6), a.highly potent, selective, orally bioavailable MMP inhibitor that has been shown to significantly inhibit tumor growth in animal cancer models.

Matrix metalloprotease inhibitors

The present invention relates to compounds of Formula I: STR1 that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.

Sulphur- and oxygen-containing diaryl compounds

The sulphur- and oxygen-containing diaryl compounds of the formula: STR1 in which A and B, which may be the same or different, represent O, S, SO or SO2, Alk is a C1 -C4 hydrocarbon radical with a straight or branched chain, R represents COOH, an esterified COOH group, a carboxylic amide group, OH, O-SO2 CH3, NH2, NHR1, NR1 R2, NHZOH, NHZNR1 R2, C(=NH)NH2, C(=NH)NHOH or 2-Δ2 -imidazolinyl, Z is a C2 -C4 hydrocarbon radical with a straight or branched chain, and R1 and R2 each represent a C1 -C3 lower alkyl group, or together form, with the nitrogen atom to which they are linked, a N-heterocyclic group of 5 to 7 ring atoms which can be substituted and can comprise a second hetero-atom, and their addition salts with bases when R is COOH, and their addition salts with acids when R is a basic radical, are useful pharmacological agents in the treatment of circulatory complaints such as cardio-vascular illnesses.