59627-41-7

Upstream product

• 1655-05-6 1-(1-propynyl)cyclohexene 
• 5877-41-8 2-ethynyl-1-cyclohexanol 
• 1940-19-8 1-vinylcyclohexanol 
• 78-27-3 1-Ethynylcyclohexan-1-ol 
• 931-49-7 1-ethenylcyclohexene 

Downstream Products

• 134197-67-4 (S^*,S^*)-2-(2-methylhexenylidene)-1-cyclohexanol 
• 107442-32-0 (S^*,S^*)-2-(2,3,3-trimethylbutenylidene)-1-cyclohexanol 
• 107442-32-0 (R^*,S^*)-2-(2,3,3-trimethylbutenylidene)-1-cyclohexanol 
• 124707-83-1 (S^*,S^*)-2-(2,3-dimethylbutenylidene)-1-cyclohexanol 
• 124707-83-1 (R^*,S^*)-2-(2,3-dimethylbutenylidene)-1-cyclohexanol 
• 107442-33-1 (S^*,S^*)-2-(2-phenylpropenylidene)-1-cyclohexanol 

Relevant academic research and scientific papers

Borylation of propargylic substrates by bimetallic catalysis. Synthesis of allenyl, propargylic, and butadienyl bpin derivatives

Bimetallic Pd/Cu and Pd/Ag catalytic systems were used for borylation of propargylic alcohol derivatives. The substrate scope includes even terminal alkynes. The reactions proceed stererospecifically with formal S N2′ pathways to give allenyl boronates. Opening of propargyl epoxides leads to 1,2-diborylated butadienes probably via en allenylboronate intermediate.

Combined rhodium/gold catalysis: From propargyloxiranes to 2,5-dihydrofurans in one pot

A new and efficient one-pot synthesis of 2,5-dihydrofurans from propargyloxiranes and arylboronic acids takes advantage of sequential rhodium-gold catalysis. The transformation proceeds with center-to-axis-to- center chirality transfer and tolerates a wide variety of electron-accepting or electron-withdrawing substituents at the arylboronic acid, as well as cyclic or acyclic propargyloxiranes.

Stereoselective synthesis of syn-configured α-allenols by rhodium-catalyzed reaction of alkynyl oxiranes with arylboronic acids

(Chemical Equation Presented) A rhodium-catalyzed reaction of alkynyl oxiranes with arylboronic acids affords syn-configured α-allenols with high diastereoselectivity. The reaction is initiated by addition of an arylrhodium(I) species onto the alkyne moie

Diastereoselective syn or anti opening of propargylic epoxides. Synthesis of α-allenic alcohols

Propargylic epoxides easily react with Grignard reagents and catalytic amounts of copper(I) salt to afford α-allenic alcohols. The reaction is highly diastereoselective and its stereochemical outcome (syn or anti isomer) can be fully controlled. The syn d