59674-85-0 Usage
Uses
Used in Pharmaceutical Industry:
7-aMinoquinazoline-2,4(1H,3H)-dione is used as a pharmaceutical candidate for its potential antitumor properties, making it a subject of research for the development of new cancer treatments. Its role as a tyrosine kinase inhibitor also highlights its potential in targeting specific enzymes involved in cancer cell growth and proliferation.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 7-aMinoquinazoline-2,4(1H,3H)-dione serves as a key compound for the synthesis and characterization of its derivatives. These derivatives may possess enhanced biological activities and improved pharmacological properties, contributing to the advancement of drug discovery and development.
Used in Drug Development:
7-aMinoquinazoline-2,4(1H,3H)-dione is utilized in drug development for its potential therapeutic applications. Ongoing research aims to uncover its full range of pharmacological properties, which may lead to the creation of novel drugs with improved efficacy and safety profiles for the treatment of various diseases, including cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 59674-85-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,6,7 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 59674-85:
(7*5)+(6*9)+(5*6)+(4*7)+(3*4)+(2*8)+(1*5)=180
180 % 10 = 0
So 59674-85-0 is a valid CAS Registry Number.
59674-85-0Relevant academic research and scientific papers
Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments
Lee, Jun Young,Shin, Young Sup,Jeon, Sangeun,Lee, Se In,Noh, Soojin,Cho, Jung-Eun,Jang, Min Seong,Kim, Seungtaek,Song, Jong Hwan,Kim, Hyoung Rae,Park, Chul Min
supporting information, (2021/03/15)
Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7-chloro-2-((3,5-dichlorophenyl)amino)quinazolin-4(3H)-one (9g) and 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one (11e) showed the most potent anti-SARS-CoV-2 activities (IC50 50 50 > 25 μM). In addition, both compounds showed acceptable results in metabolic stabilities, hERG binding affinities, CYP inhibitions, and preliminary PK studies.
Fluorescent nucleoside analogue displays enhanced emission upon pairing with guanine
Xie, Yun,Maxson, Tucker,Tor, Yitzhak
supporting information; experimental part, p. 5053 - 5055 (2010/12/24)
A fluorescent nucleobase analogue, 7-aminoquinazoline-2,4-(1H,3H)-dione, is incorporated into a DNA oligonucleotide and senses mismatched pairing by displaying G-specific fluorescence enhancement.
