596808-27-4Relevant academic research and scientific papers
Synthesis and biological evaluation of pyridooxazine-tetrahydroisoquinoline derivatives as MDR modulators
Ma, Chen,Liu, Shao-Jie,Xin, Liang,Zhang, Qun,Ding, Kai,Falck,Shin, Dong-Soo
, p. 1010 - 1011 (2007/10/03)
Pyridooxazine-tetrahydroisoquinoline derivatives were designed and synthesized for MDR modulating activity. Pyridooxazin-2-one scaffolds were constructed in a one-pot annulation of N-substituted-2-chloroacetamides with 2-bromo-3-hydroxy pyridine via Smile
A one-pot synthesis of pyrido[2,3.b][1,4]oxazin-2-ones
Cho, Su-Dong,Park, Yong-Dae,Kim, Jeum-Jong,Lee, Sang-Gyeong,Ma, Chen,Song, Sang-Yong,Joo, Woo-Hong,Falck,Shiro, Motoo,Shin, Dong-Soo,Yoon, Yong-Jin
, p. 7918 - 7920 (2007/10/03)
Pyrido[2,3-b][1,4]oxazin-2-ones are conveniently prepared in excellent yields by a one-pot annulation of N-substituted-2-chloroacetamides with 2-halo-3-hydroxypyridines with use of cesium carbonate in refluxing acetonitrile. The key transformation features a Smiles rearrangement of the initial O-alkylation product and subsequent cyclization.
