596820-24-5Relevant academic research and scientific papers
Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors
Foss Jr., Frank W.,Clemens, Jeremy J.,Davis, Michael D.,Snyder, Ashley H.,Zigler, Molly A.,Lynch, Kevin R.,Macdonald, Timothy L.
, p. 4470 - 4474 (2007/10/03)
Phosphothioates may provide metabolic stability when compared to their phosphate counterparts, while retaining the potency and efficacy as agonists at sphingosine-1-phosphate (S1P) G-protein coupled receptors. Unlike their phosphate precursors, phosphothi
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720
Hale, Jeffrey J.,Neway, William,Mills, Sander G.,Hajdu, Richard,Ann Keohane, Carol,Rosenbach, Mark,Milligan, James,Shei, Gan-Ju,Chrebet, Gary,Bergstrom, James,Card, Deborah,Koo, Gloria C.,Koprak, Sam L.,Jackson, Jesse J.,Rosen, Hugh,Mandala, Suzanne
, p. 3351 - 3355 (2007/10/03)
Alteration in lymphocyte trafficking and prevention of graft rejection in rodents observed on exposure to FTY720 (1) or its corresponding phosphate ester 2 can be induced by the systemic administration of potent sphingosine-1- phosphate receptor agonists
