59686-54-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 7101-51-1 (+/-)-3-(3,4-dihydroxyphenyl)-2-methyl-DL-alanine 
• 63-84-3 dopa 
• 1421-65-4 L-dopa methyl ester hydrochloride 

Downstream Products

• 125228-11-7 3-(3,4-Bis-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 217975-69-4 3-(3.4-Bis-trifluoromethanesulfonyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 19937-29-2 Boc-DOPA-(Bn)2-OH 
• 125353-55-1 [2-(3,4-Bis-benzyloxy-phenyl)-1-carbamoyl-ethyl]-carbamic acid tert-butyl ester 
• 125228-12-8 2-Amino-3-(3,4-bis-benzyloxy-phenyl)-propionamide 
• 125279-75-6 4-(3,4-Bis-benzyloxy-benzyl)-imidazolidine 
• 125228-13-9 3-(3,4-Bis-benzyloxy-phenyl)-propane-1,2-diamine 

Relevant academic research and scientific papers

Signal transduction inhibitors, compositions containing them

This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to p

Bicyclic signal transduction inhibitors, compositions containing them and uses thereof

This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to

Synthesis of novel functionalised zinc phthalocyanines applicable in photodynamic therapy

The synthesis of several new phthalonitriles 3, 9, 14, 25, 33, and 36, functionalised with carboxyl groups, including two examples of amino acid derivatives is described. All new phthalonitriles were converted into their corresponding phthalocyaninatozinc compounds. The phthalocyanines, 2,3,9,10,16,17,23,24-octa(1-carboxyethyloxy)phthalocyaninatozinc (5), 2,9,16,23-tetra(2-amino-2-carboxyethyl)phthalocyaninatozinc (11), 2,9,16,23- tetra(1-carboxy-2-hydroxyethylaminocarbonyl)phthalocyaninatozinc (16), 1,8,15,22-tetra(carboxybutyl)phthalocyaninatozinc (27), 2,3,9,10,16,17,23,24- octa(carboxyalkyl)phthalocyaninatozinc (39), and the nonidentically substituted 9,10,16,17,23,24-hexa(carboxyalkyl)-2-[4-(N- succinimidyloxycarbonyl)butyl]phthaloyaninatozinc (41) are all sufficiently soluble in water. The nonidentically-substituted compounds are important due to their selective binding to tumor-selective antibodies. UV/Vis-spectroscopy was used to investigate the effect of more or less sterically-demanding substituents in the periphery of the phthalocyanines towards aggregation. The phototoxicity towards cancer cells of some of the new compounds was investigated in several in-vitro experiments.