217975-69-4

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 59686-54-3 methyl N-(tert-butyloxycarbonyl)-3,4-bis(hydroxy)phenylalanine carboxylate 
• 63-84-3 dopa 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 7101-51-1 (+/-)-3-(3,4-dihydroxyphenyl)-2-methyl-DL-alanine 

Relevant academic research and scientific papers

Bicyclic signal transduction inhibitors, compositions containing them and uses thereof

This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to

Synthesis of novel functionalised zinc phthalocyanines applicable in photodynamic therapy

The synthesis of several new phthalonitriles 3, 9, 14, 25, 33, and 36, functionalised with carboxyl groups, including two examples of amino acid derivatives is described. All new phthalonitriles were converted into their corresponding phthalocyaninatozinc compounds. The phthalocyanines, 2,3,9,10,16,17,23,24-octa(1-carboxyethyloxy)phthalocyaninatozinc (5), 2,9,16,23-tetra(2-amino-2-carboxyethyl)phthalocyaninatozinc (11), 2,9,16,23- tetra(1-carboxy-2-hydroxyethylaminocarbonyl)phthalocyaninatozinc (16), 1,8,15,22-tetra(carboxybutyl)phthalocyaninatozinc (27), 2,3,9,10,16,17,23,24- octa(carboxyalkyl)phthalocyaninatozinc (39), and the nonidentically substituted 9,10,16,17,23,24-hexa(carboxyalkyl)-2-[4-(N- succinimidyloxycarbonyl)butyl]phthaloyaninatozinc (41) are all sufficiently soluble in water. The nonidentically-substituted compounds are important due to their selective binding to tumor-selective antibodies. UV/Vis-spectroscopy was used to investigate the effect of more or less sterically-demanding substituents in the periphery of the phthalocyanines towards aggregation. The phototoxicity towards cancer cells of some of the new compounds was investigated in several in-vitro experiments.

An easy route from catechols to phthalonitriles

An easy synthetic route from substituted catechols via their corresponding aryl bistriflates to substituted phthalonitriles is described. The displacement of the triflate groups in catechol triflates by cyanide ions proceeded in high yields using zinc cyanide and palladium-1,1′-bis(diphenylphosphino)ferrocene as catalyst. The mild reaction conditions tolerate numerous functional groups and represent a desirable alternative to the generally low-yielding Rosenmund-von Braun reaction.