59690-97-0

Basic information

• Product Name: 10-bromocarbamazepine
• Synonyms: 10-BroMo-5H-Dibenz[B,F]Azepine-5-CarboxaMide;10-BroMo-5H-dibenzo[b,f]azepine-5-carboxaMide;Carbamazepine EP Impurity G;5-bromobenzo[b][1]benzazepine-11-carboxamide
• CAS NO: 59690-97-0
• Molecular Formula: C₁₅H₁₁BrN₂O
• Molecular Weight: 315.169
• Mol File: 59690-97-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 463.091 °C at 760 mmHg
• Flash Point: 233.869 °C
• Appearance: /
• Density: 1.584 g/cm³
• Vapor Pressure: 9.35E-09mmHg at 25°C
• Refractive Index: 1.706
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.81±0.40(Predicted)
• CAS DataBase Reference: 10-bromocarbamazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 10-bromocarbamazepine(59690-97-0)
• EPA Substance Registry System: 10-bromocarbamazepine(59690-97-0)

Safety Data

• Hazardous Substances Data: 59690-97-0(Hazardous Substances Data)

Usage

Uses

10-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide is a Carbamazepine (C175840(P)) impurity, which has been used in treatment of pain associated with trigeminal neuralgia. It is an anticonvulsant, neuroprotective & neuroresearch product.

InChI:InChI=1/C15H11BrN2O/c16-12-9-10-5-1-3-7-13(10)18(15(17)19)14-8-4-2-6-11(12)14/h1-9H,(H2,17,19)

Upstream product

• 143667-53-2 10-Brom-5-chlorcarbonyl-5H-dibenzazepin 
• 33948-19-5 10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride 
• 494-19-9 9,10-dihydrodibenzazepine 

Downstream Products

• 298-46-4 carbamazepin 
• 28721-07-5 oxcarbazepine 

Relevant articles and documents

Synthetic method of oxcarbazepine

The invention relates to a synthetic method of oxcarbazepine. According to the method, the oxcarbazepine is prepared from iminodibenzyl as a raw material through formyl chlorination, dihalogenated dehydrohalogenation, ammonification and hydrolyzation; a product obtained after formyl chlorination is iminodibenzyl-5-carbonyl chloride, wherein the dihalogenated dehydrohalogenation process specifically comprises the step that the iminodibenzyl-5-carbonyl chloride and a halogenating reagent react for 3-6 h at the temperature ranging from 80 DEG C to the reflux temperature in the presence of an organic solvent and an initiating agent to obtain a disubstituted halogenated product, then the disubstituted halogenated product reacts for 8-16 h at the reflux temperature to be subjected to dehydrohalogenation to obtain 10-halo-5H-dibenzoazepine-5-formyl chloride. The method has the advantages that starting materials are low in price and easy to obtain; the processing step is short; the yield is high; and the cost is low.