59697-06-2

Basic information

• Product Name: 1-Propanol,3-[(1,1-dimethylethyl)amino]-2-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]-oxy]-
• Synonyms: Timolol impurity B (racemic);1-Propanol,3-[(1,1-dimethylethyl)amino]-2-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]-oxy]-;IsotiMolol;3-[(1,1-DiMethylethyl)aMino]-2-[[4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-1-propanol;TiMolol IMpurity B (IsotiMolol)
• CAS NO: 59697-06-2
• Molecular Formula: C₁₃H₂₄N₄O₃S
• Molecular Weight: 316.41966
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 59697-06-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 120.0-121.5 °C(Solv: hexane (110-54-3))
• Boiling Point: 484.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.224±0.06 g/cm3(Predicted)
• PKA: 13.84±0.10(Predicted)
• CAS DataBase Reference: 1-Propanol,3-[(1,1-dimethylethyl)amino]-2-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]-oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol,3-[(1,1-dimethylethyl)amino]-2-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]-oxy]-(59697-06-2)
• EPA Substance Registry System: 1-Propanol,3-[(1,1-dimethylethyl)amino]-2-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]-oxy]-(59697-06-2)

Safety Data

• Hazardous Substances Data: 59697-06-2(Hazardous Substances Data)

Usage

Uses

rac-Isotimolol (Timolol EP Impurity B; Timolol BP Impurity B; Timolol USP Related Compound B) is an analog of Timolol (T443700); an antihypertensive, antiarrhythmic (class II), antianginal, and antiglaucoma agent.

Upstream product

• 30315-46-9 (S)-1-tert-butylamino-2,3-dihydroxypropane 
• 30165-96-9 3-Morpholino-4-chloro-1,2,5-thiadiazole 
• 194861-99-9 ((2Ξ,5S)-3-tert-butyl-2-phenyl-oxazolidin-5-yl)-methanol 

Relevant articles and documents

Synthesis of the β adrenergic blocking agent timolol from optically active precursors

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