59699-19-3Relevant academic research and scientific papers
Lithiation of Polyhydric Compounds. Salicylic Acids
Rotger, M. Carmen,Costa, Antoni,Saa, Jose M.
, p. 4083 - 4087 (1993)
Polylithiated derivatives of salicylic and oligosalicylic acids can be generated by means of the halogen-to-metal exchange reaction.Dehydrobromination and other byproducts can be kept to a minimum by working with the preformed lithium salts which are soluble in THF.Even base sensitive salicylic acids such as 6-bromolasalocid acid can be functionalized under these conditions.
Benzothiophenes and benzofurans and antiallergic use thereof
-
, (2008/06/13)
Novel benzothiophene and benzofuran derivatives having antiallergic activity are described as well as a method of manufacture, pharmaceutical compositions, and methods of use therefor. The disclosure describes the use of derivatives for prevention of the release of mediators including histamine and leukotrienes from basophils and mast cells, and prevent respiratory burst in neutrophils providing activity useful in cardiovascular disorders as well as in antiinflammatory, psoriasis, and antimigraine treatment.
