
Journal of Organic Chemistry p. 4083 - 4087 (1993)
Update date:2022-08-02
Topics:
Rotger, M. Carmen
Costa, Antoni
Saa, Jose M.
Polylithiated derivatives of salicylic and oligosalicylic acids can be generated by means of the halogen-to-metal exchange reaction.Dehydrobromination and other byproducts can be kept to a minimum by working with the preformed lithium salts which are soluble in THF.Even base sensitive salicylic acids such as 6-bromolasalocid acid can be functionalized under these conditions.
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