59703-84-3

Basic information

• Product Name: Piperacillin sodium salt
• Synonyms: PIPERACILLIN SODIUM;PIPERACILLIN NA;[2s-[2alpha,5alpha,6beta(s*)]]-6-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt;(2s-(2-alpha,5-alpha,6-beta(s*)))-msal;3-dimethyl-7-oxo--piperazinyl)carbonyl)amino)phenylacetyl)amino)-monosodiu;4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((((4-ethyl-2,3-dioxo-1;cl227193;pentcillin
• CAS NO: 59703-84-3
• Molecular Formula: C₂₃H₂₆N₅O₇S*Na
• Molecular Weight: 539.54
• EINECS: 261-868-6
• Product Categories: Antibiotics for Research and Experimental Use;beta-Lactams (Antibiotics for Research and Experimental Use);Biochemistry;Antibiotic Explorer;Interferes with Cell Wall SynthesisSpectrum of Activity;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics N-SAntibiotics;Chemical Structure Class;L - ZAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);PIPRACIL
• Mol File: 59703-84-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 183-185 C (dec.)
• Boiling Point: 793℃
• Flash Point: 381.4oC
• Appearance: White to off-white crystalline powder
• Density: ==
• Vapor Pressure: 5.55E-21mmHg at 25°C
• Refractive Index: 180 ° (C=0.8, H2O)
• Storage Temp.: Store at 0-5°C
• Solubility: H2O: 50 mg/mL, clear, colorless to faintly yellow
• Water Solubility: Soluble in ethanol, water and methanol.
• Merck: 14,7463
• BRN: 5373920
• CAS DataBase Reference: Piperacillin sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Piperacillin sodium salt(59703-84-3)
• EPA Substance Registry System: Piperacillin sodium salt(59703-84-3)

Safety Data

• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37-45
• WGK Germany: 2
• RTECS: XI0180000
• Hazardous Substances Data: 59703-84-3(Hazardous Substances Data)

Usage

Brand Name(s) in US

Pipracil

Chemical Properties

White to off-white crystalline powder

Uses

Different sources of media describe the Uses of 59703-84-3 differently. You can refer to the following data:
1. Penicillin antibacterial.
2. An antibiotic related to penicillin
3. A broad spectrum antibiotic targeting a wide range of susceptible gram positive and gram negative bacteria. Piperacillin sodium salt is an antibiotic. It is used in pharmacokinetic studies to optimize antimicrobial therapy and in hypersensitivity reactions. It is involved in the study of multidrug-resistant organisms. It acts as an antibiotic related to penicillin.

Brand name

Pipracil (Wyeth).

InChI:InChI=1/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1

Upstream product

• 89786-04-9 tazobactam acid 
• 61477-96-1 piperacillin 

Downstream Products

• 61477-96-1 piperacillin 

Relevant articles and documents

Piperacillin sodium compound containing half water

The invention discloses a piperacillin sodium compound containing half water and a preparation method thereof. Each mole of piperacillin sodium contains a half mole of water. First, ampicillin trihydrate is reacted with 4-ethyl-2,3-dioxypiperazine formyl chloride to form piperacillin acid, then piperacillin acid is reacted with sodium acetate in a mixed solution of acetone and water, isopropanol is added dropwise, and crystallization, filtration and drying are conducted to obtain the piperacillin sodium compound containing half water. The piperacillin sodium compound containing half water hashigh fluidity, low hygroscopicity and impurity content, high thermodynamic stability and a wider application prospect.

Process for the preparation of 6-[D(-)alpha-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-alpha-phenylacetamido]-penicillanic acid and intermediates useful in this process

The 6-[D(-)-alpha(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-alphaphenylacetamido]penicillanic acid and the salts thereof are prepared by synthetizing the novel intermediates, thioesters of D(-)-alpha-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-alpha-phenylacetic acid, with mercaptoheterocycles and by converting them into the desired compound by reaction with 6-amino-penicillanic acid.