59721-29-8 Usage
Description
Camostat mesylate is a broad spectrum protease inhibitor useful in the treatment
of chronic pancreatitis.
Chemical Properties
Crystalline Solid
Originator
Ono (Japan)
Uses
Different sources of media describe the Uses of 59721-29-8 differently. You can refer to the following data:
1. It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.
2. Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor
Brand name
FOIPAN
Biological Activity
Orally active protease inhibitor. Known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration.
References
1) Gibo?et al.?(2005),?Camostat mesylate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity;?Lab Invest.,?85?75
2) Albarazanji?et al.?(2019),?Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.; Am. J. Physiol. Gastrointest. Liver Physiol.,?316?G653
3) Ueda?et al.?(2015),?The serine protease inhibitor camostat mesylate attenuates the progression of chronic kidney disease through its antioxidant effects; Nephron,?129?223
4) Yamaya?et al.?(2015),?The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells; Pulm. Pharmacol. Ther.,?33?66
5) Hoffmann?et al.?(2020),?SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor; Cell, 181 271
Check Digit Verification of cas no
The CAS Registry Mumber 59721-29-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,7,2 and 1 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 59721-29:
(7*5)+(6*9)+(5*7)+(4*2)+(3*1)+(2*2)+(1*9)=148
148 % 10 = 8
So 59721-29-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
59721-29-8Relevant articles and documents
Crystal forms of camostat mesilate and solvate thereof as well as preparation method and application of crystal forms of camostat mesylate and solvate thereof
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Paragraph 0064-0065, (2021/11/26)
The invention provides a crystal form of camostat mesylate, a crystal form of an acetone solvate of the camostat mesylate, and preparation methods and applications of the crystal forms of the camostat mesylate and the solvate thereof. The invention provides application of the crystal form and the crystal form of the acetone solvate in preparation of medicines for treating pancreatitis, reflux esophagitis and diseases caused by coronavirus infection. Compared with the mixed crystal form of the camostat mesylate, the crystal form of the camostat mesylate and the crystal form of the acetone solvate of the camostat mesylate provided by the invention have better stability, and the physicochemical properties of the camostat mesylate and the acetone solvate of the camostat mesylate are more stable than those of the existing crystal form in the preparation process.
